SCHEMBL4086004

SCHEMBL4086004

C=CC(F)(F)c1cc(N)cc(C(=O)O)n1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
HIF1A Q16665 1/20 0.35
ASPH Q12797 1/20 0.31
IGFBP3 P17936 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30697188 0.82 ALOX15 (0.41) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL27077029 0.82 ALOX15 (0.41) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL742374 0.73 TSHR (0.61) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL745813 0.73 TSHR (0.61) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL30938840 0.71 TSHR (0.58) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL29254156 0.71 TSHR (0.58) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL22695513 0.68 LMNA (0.42)
SCHEMBL6121546 0.68 ALOX15 (0.37) ALOX15TSHRHIF1AASPHIGFBP3
SCHEMBL29882592 0.67 HSP90AA1 (0.42)
SCHEMBL18839634 0.67 HSP90AA1 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651607-B1 6-(1,1-DIFLUOROALKYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-05-06 EP disclosed
CN-100412061-C 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-08-20 CN disclosed
US-7291580-B2 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-06 US disclosed
US-7291580-B2 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-06 US disclosed
CN-1823045-A 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2006-08-23 CN disclosed
EP-1651607-A1 6-(1,1-DIFLUOROALKYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2006-05-03 EP disclosed
WO-2005016887-A1 6-(1,1-DIFLUOROALKYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-24 WO disclosed
US-20050032651-A1 6-(1,1-Difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2005-02-10 US disclosed
US-20050032651-A1 6-(1,1-Difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2005-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050032651-A1 6-(1,1-Difluoroalkyl)-4-aminopicolinates and their use as herbicides DDT, ALDH7A1, DDC ALOX15 3926/4885TSHR 3567/4885HIF1A 4001/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.