Sugi Predict

Sugi Predict / Compounds / SCHEMBL4087719

SCHEMBL4087719

SCHEMBL4087719

C[Si](C)(C)n1ncc2c(Cl)ncnc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PI4KA P42356 1/20 0.37
▸ PI4K2B Q8TCG2 1/20 0.37
▸ PI4K2A Q9BTU6 1/20 0.37
▸ PI4KB Q9UBF8 1/20 0.37
▸ SELE P16581 1/20 0.34
▸ VCAM1 P19320 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ PDE4A P27815 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ PDE4C Q08493 1/20 0.33
▸ PDE4D Q08499 1/20 0.33
▸ NPC1 O15118 4/20 0.33
▸ RAB9A P51151 4/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ SMN1; SMN2 Q16637 3/20 0.33
▸ TP53 P04637 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13510 0.77 PI4KA (0.61) PI4KAPI4K2BPI4K2API4KBMEN1
SCHEMBL839258 0.73 GSK3B (0.38) PI4KAPI4K2BPI4K2API4KBMEN1
SCHEMBL28645698 0.73 XDH (0.59) MEN1KMT2AHTTHSD17B10MAPK1
SCHEMBL29863560 0.73 XDH (0.59) MEN1KMT2AHTTHSD17B10MAPK1
SCHEMBL22521558 0.73 ABL1 (0.45) PI4KAPI4K2BPI4K2API4KBMEN1
SCHEMBL2303091 0.70 NPC1 (0.51) MEN1KMT2ANPC1RAB9AKDM4E
SCHEMBL19826086 0.69 PI4KA (0.33) PI4KAPI4K2BPI4K2API4KBPDE4A
SCHEMBL11595465 0.69 SIGMAR1 (0.43) SMN1; SMN2HPGDHTTMAPK1PKM
SCHEMBL6269930 0.68 XDH (0.68) NPC1RAB9AKDM4ESMN1; SMN2TP53
SCHEMBL3425282 0.68 NPC1 (0.51) MEN1KMT2ANPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025202889-A1 HER2 MUTATION INHIBITORS ARRAY BIOPHARMA INC. (US) 2025-10-02 — — WO disclosed
US-7491818-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2009-02-17 — — US disclosed
US-7423143-B2 Nucleic acid labeling compounds AFFYMETRIX. INC. (US) 2008-09-09 — — US disclosed
US-7291463-B2 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2007-11-06 — — US disclosed
US-7282327-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-10-16 — — US disclosed
US-7179905-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-02-20 — — US disclosed
US-20050287563-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-12-29 — — US disclosed
US-6965020-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2005-11-15 — — US disclosed
EP-1589025-A2 Nucleic acid labeling compounds Affymetrix, Inc. (US) 2005-10-26 — — EP disclosed
US-20050164268-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-07-28 — — US disclosed
US-20050003496-A1 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2005-01-06 — — US disclosed
US-20040210045-A1 Nucleic acid labeling compounds MCGALL GLENN (US) 2004-10-21 — — US disclosed
US-20040101892-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-05-27 — — US disclosed
US-20040002595-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-01-01 — — US disclosed
US-20030232979-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-12-18 — — US disclosed
US-20030180757-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-09-25 — — US disclosed
US-6596856-B2 For probes, comprising a heterocycle condensed with a cyclic group such as ribofuranose derivative; biotin and 5-carboxyfluorescein derivatives AFFYMETRIX, INC. 2003-07-22 — — US disclosed
US-20020165372-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2002-11-07 — — US disclosed
US-20010044531-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2001-11-22 — — US disclosed
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. 2001-08-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040002595-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20030180757-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20050164268-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20040101892-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20010044531-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20050287563-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20020165372-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20030232979-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885
US-20050003496-A1 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis DUT, PCNA, BCDIN3D PI4KA 2736/4885PI4K2B 3511/4885PI4K2A 3270/4885
US-20040210045-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL PI4KA 4122/4885PI4K2B 4478/4885PI4K2A 4436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.