Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087878 | 0.80 | KDM4E (0.41) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16323431 | 0.77 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL16323432 | 0.75 | P2RX7 (0.31) | LMNA | |
| Hydrochloric Acid SCHEMBL13860004 | 0.65 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL5533938 | 0.59 | TRPV4 (0.34) | — | |
| SCHEMBL16361383 | 0.59 | LMNA (0.39) | ALDH1A1LMNAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL13860011 | 0.56 | TRPV4 (0.41) | — | |
| SCHEMBL31399295 | 0.53 | TSHR (0.39) | ALDH1A1LMNAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL152358 | 0.53 | TSHR (0.39) | ALDH1A1LMNAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL9289876 | 0.52 | KDM4E (0.50) | ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054410-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | Wyeth (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021331-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | claimed |
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |