Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088412 | 0.94 | ABL1 (0.51) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL4086294 | 0.94 | ABL1 (0.52) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL4088344 | 0.93 | RAB9A (0.46) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL4082899 | 0.90 | AURKA (0.60) | AURKAABL1BCRFLT3KIT | |
| SCHEMBL4081436 | 0.90 | AURKA (0.57) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL13850096 | 0.86 | AURKA (0.39) | AURKAABL1BCRFLT3DYRK1A | |
| SCHEMBL4084047 | 0.86 | AURKA (0.42) | AURKANTRK1HDAC1HDAC6 | |
| SCHEMBL4081802 | 0.84 | FLT3 (0.43) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL4083868 | 0.84 | ABL1 (0.59) | AURKAKDRABL1BCRFLT3 | |
| SCHEMBL4092903 | 0.84 | ABL1 (0.61) | AURKAKDRABL1BCRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |