Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.39 |
| ▸ | CHRNG | P07510 | 3/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | CHRND | Q07001 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201107 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL2961890 | 0.98 | ALDH1A1 (0.42) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL3898658 | 0.96 | ALDH1A1 (0.43) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL6129180 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL27793003 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL7297454 | 0.82 | ALDH1A1 (0.65) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL16496970 | 0.82 | KDM4E (0.46) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL2110264 | 0.82 | SIGMAR1 (0.42) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL3358932 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPTNPSR1LMNAHPGD | |
| SCHEMBL3353702 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPTNPSR1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104662004-B | Novel rebamipide prodrug, method for producing same, and usage thereof | 三进制药株式会社 | 2017-04-19 | — | — | CN | claimed |
| US-10766882-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | YUNGJIN PHARM CO., LTD. (KR) | 2020-09-08 | — | — | US | disclosed |
| US-9975883-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | YUNGJIN PHARM. CO., LTD. (KR) | 2018-05-22 | — | — | US | disclosed |
| US-9975883-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | YUNGJIN PHARM. CO., LTD. (KR) | 2018-05-22 | — | — | US | disclosed |
| CN-107759503-A | A kind of tetracycline derivant and application thereof | 四川科伦博泰生物医药股份有限公司 | 2018-03-06 | — | — | CN | disclosed |
| US-20160376258-A1 | 1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME | KT&G LIFE SCIENCES CORPORATION (KR) | 2016-12-29 | — | — | US | disclosed |
| WO-2015102371-A1 | 1,2-NAPHTHOQUINONE DERIVATIVE AND METHOD FOR PREPARING SAME | 주식회사 케이티앤지생명과학 | 2015-07-09 | — | — | WO | disclosed |
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-6977303-B2 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | EASTMAN CHEMICAL COMPANY (US) | 2005-12-20 | — | — | US | disclosed |
| US-20050171082-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2005-08-04 | — | — | US | disclosed |
| WO-2005051942-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-06-09 | — | — | WO | disclosed |
| US-6897323-B2 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | EASTMAN CHEMICAL COMPANY (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040106593-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2004-06-03 | — | — | US | disclosed |
| US-20040106788-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2004-06-03 | — | — | US | disclosed |
| US-6686477-B2 | MULTISTEP CHEMICAL SYNTHESIS, INCLUDING ASYMMETRIC HYDROGENATION OF A LACTAM-ENAMIDE TO PRODUCE AN INTERMEDIATE THAT CAN BE USED TO MAKE UNSPECIFIED PHARMACEUTICALS | EASTMAN CHEMICAL COMPANY | 2004-02-03 | — | — | US | disclosed |
| EP-1322609-A2 | HIGHLY ENANTIOMERICALLY PURE LACTAM-SUBSTITUTED PROPANOIC ACID DERIVATIVES AND THEIR PREPARATION | EASTMAN CHEMICAL COMPANY (US) | 2003-07-02 | — | — | EP | disclosed |
| US-20020042508-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2002-04-11 | — | — | US | disclosed |
| WO-2002026705-A2 | HIGHLY ENANTIOMERICALLY PURE LACTAM-SUBSTITUTED PROPANOIC ACID DERIVATIVES AND THEIR PREPARATION | EASTMAN CHEMICAL COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042508-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | COASY, ACSL4, ACSL1 | ALDH1A1 804/4885MAPT 3373/4885NPSR1 2052/4885 |
| US-10766882-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | CYP2S1, GYS2, SLC5A1 | ALDH1A1 688/4885MAPT 141/4885NPSR1 1141/4885 |
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | GRM5, GRIK5, GRM2 | ALDH1A1 2494/4885MAPT 4176/4885NPSR1 222/4885 |
| US-20160376258-A1 | 1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME | CYP2S1, GYS2, SLC5A1 | ALDH1A1 688/4885MAPT 141/4885NPSR1 1141/4885 |
| US-20050171082-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | COASY, ACSL4, ACSL1 | ALDH1A1 804/4885MAPT 3373/4885NPSR1 2052/4885 |
| US-20040106788-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | COASY, ACSL4, ACSL1 | ALDH1A1 804/4885MAPT 3373/4885NPSR1 2052/4885 |
| US-20040106593-A1 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same | COASY, ACSL4, ACSL1 | ALDH1A1 804/4885MAPT 3373/4885NPSR1 2052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.