Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.81 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017773 | 0.77 | CYP11B1 (0.63) | NAMPTCYP11B1CYP11B2LMNAHIF1A | |
| SCHEMBL30533390 | 0.77 | LMNA (0.81) | NAMPTCYP11B1CYP11B2LMNAHIF1A | |
| SCHEMBL13095736 | 0.75 | CYP11B1 (0.68) | NAMPTCYP11B1CYP11B2TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL4079710 | 0.75 | RAB9A (0.69) | LMNANPC1SIRT2RAB9A | |
| SCHEMBL7405091 | 0.74 | RAB9A (0.78) | TP53LMNANPC1GAARAB9A | |
| SCHEMBL5214172 | 0.74 | CSF1R (0.83) | NAMPTCYP11B1CYP11B2LMNAHIF1A | |
| SCHEMBL1571386 | 0.74 | LMNA (1.00) | NAMPTCYP11B1CYP11B2LMNAHIF1A | |
| SCHEMBL3642636 | 0.73 | NAMPT (0.81) | NAMPTCYP11B1CYP11B2TP53LMNA | |
| SCHEMBL5435462 | 0.73 | NAMPT (0.76) | NAMPTCYP11B1CYP11B2TP53LMNA | |
| SCHEMBL14082904 | 0.73 | NAMPT (0.67) | NAMPTCYP11B1CYP11B2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547691-B2 | [4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases | ELI LILLY AND COMPANY (US) | 2009-06-16 | — | — | US | disclosed |
| US-20080306082-A1 | [4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases | ELI LILLY AND COMPANY | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306082-A1 | [4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases | NFKBIA, IKBKB, IKBKG | NAMPT 1183/4885CYP11B1 947/4885CYP11B2 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.