Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4091036 | 0.88 | PRKCA (0.31) | FPR2NFKB1NFKB2RELA | |
| Demannose SCHEMBL27882113 | 0.85 | LMNA (0.37) | FPR2NFKB1NFKB2RELAPDE4A | |
| Demannose SCHEMBL28531529 | 0.85 | FFAR3 (0.43) | FPR2NFKB1NFKB2RELAFFAR3 | |
| Demannose SCHEMBL5586151 | 0.84 | FFAR3 (0.45) | FPR2NFKB1NFKB2RELAFFAR3 | |
| Demannose SCHEMBL27660938 | 0.84 | FFAR3 (0.45) | FPR2NFKB1NFKB2RELAFFAR3 | |
| Demannose SCHEMBL18141631 | 0.81 | FPR2 (0.44) | FPR2NFKB1NFKB2RELAPDE4A | |
| Demannose SCHEMBL28742780 | 0.81 | FPR2 (0.44) | FPR2NFKB1NFKB2RELAPDE4A | |
| Demannose SCHEMBL30163433 | 0.81 | FPR2 (0.44) | FPR2NFKB1NFKB2RELAPDE4A | |
| Lactic Acid SCHEMBL18423690 | 0.81 | FFAR3 (0.42) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Demannose SCHEMBL20765370 | 0.81 | LMNA (0.41) | PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102351-A1 | METHOD FOR PREPARING BUTANOL THROUGH BUTYRYL-COA AS AN INTERMEDIATE USING BACTERIA | Biofuelchem Co., Ltd. (KR) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008072920-A1 | METHOD FOR PREPARING BUTANOL THROUGH BUTYRYL-COA AS AN INTERMEDIATE USING BACTERIA | BIOFUELCHEM CO., LTD. (KR) | 2008-06-19 | — | — | WO | disclosed |