Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088594 | 0.88 | GPR35 (0.55) | NPC1RAB9ACDK2CDK7HDAC6 | |
| SCHEMBL4088617 | 0.86 | CDK7 (0.46) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL4083540 | 0.85 | FGFR1 (0.50) | NPC1RAB9ACDK2CDC7DAPK3 | |
| SCHEMBL4088652 | 0.84 | JAK2 (0.49) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL4088257 | 0.84 | AURKA (0.47) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL4081022 | 0.83 | FLT3 (0.50) | SMN1; SMN2NPC1RAB9AFLT3HDAC6 | |
| SCHEMBL6376887 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL4091966 | 0.80 | GPR35 (0.54) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL1179465 | 0.79 | CDK7 (0.62) | CDK2CDC7DAPK3JAK2ROCK2 | |
| SCHEMBL2913699 | 0.78 | GPR35 (0.51) | NPC1RAB9ACDK7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |