Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.88 | FGFR1 (0.50) | JAK2JAK1NPC1RAB9ACDK2 | |
| SCHEMBL4092896 | 0.87 | HDAC6 (0.51) | NPC1RAB9ACDK2CDC7DAPK3 | |
| SCHEMBL4088257 | 0.86 | AURKA (0.47) | JAK2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL4091914 | 0.84 | SMN1; SMN2 (0.51) | JAK2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL2913699 | 0.81 | GPR35 (0.51) | NPC1RAB9ACDK7GPR35MEN1 | |
| SCHEMBL3879252 | 0.80 | GPR35 (0.45) | NPC1RAB9ACDK2CDC7DAPK3 | |
| SCHEMBL4078664 | 0.79 | HPGD (0.44) | NPC1RAB9ACDK2GSK3BCDK7 | |
| SCHEMBL4088586 | 0.79 | KCNK3 (0.42) | RAB9AGSK3BHDAC6GPR35KCNK3 | |
| SCHEMBL4078387 | 0.79 | MAPK1 (0.48) | NPC1RAB9AHDAC6KCNK3KCNK9 | |
| SCHEMBL4081022 | 0.79 | FLT3 (0.50) | NPC1RAB9AFLT3HDAC6GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |