Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12593806 | 0.85 | TDP1 (0.47) | KMT2AMEN1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL1108991 | 0.83 | ALDH1A1 (0.55) | KMT2AMEN1HTTNPSR1ALDH1A1 | |
| SCHEMBL10403783 | 0.83 | L3MBTL1 (0.43) | KCNH2L3MBTL1MDM2HTTALDH1A1 | |
| SCHEMBL13240400 | 0.83 | KMT2A (0.51) | KMT2ATSHRMEN1PGRADRA2A | |
| SCHEMBL5062402 | 0.83 | ALDH1A1 (0.48) | KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL5395543 | 0.83 | AKT1 (0.48) | KCNA5KMT2ATSHRAKT1ESRRB | |
| SCHEMBL10050539 | 0.82 | SMN1; SMN2 (0.40) | KCNA5L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL27682310 | 0.82 | ALDH1A1 (0.44) | KCNA5KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL22076551 | 0.81 | KMT2A (0.49) | KCNA5KMT2ATSHRPOLBMEN1 | |
| SCHEMBL8535929 | 0.81 | KCNA5 (0.49) | KCNA5KMT2ATSHRPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980887-B2 | 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY (CN) | 2015-03-17 | — | — | US | disclosed |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-08-08 | — | — | US | disclosed |
| US-20090221604-A1 | Thiazole Compounds and Their Use as PGD2 Antagonists | ARGENTA DISCOVERY LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| EP-1922312-A1 | THIAZOLE COMPOUNDS AND THEIR USE AS PGD2 ANTAGONISTS | Argenta Discovery Limited (GB) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007028999-A1 | THIAZOLE COMPOUNDS AND THEIR USE AS PGD2 ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |
| US-4596816-A | Pharmaceuticals | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-06-24 | — | — | US | disclosed |
| EP-0092239-A2 | Oxazole derivatives, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1983-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | TSPO, SLC6A1, TBXA2R | KCNA5 674/4885KMT2A 2294/4885TSHR 548/4885 |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | HRH1, HRH2, HRH3 | KCNA5 2962/4885KMT2A 3740/4885TSHR 93/4885 |
| US-20090221604-A1 | Thiazole Compounds and Their Use as PGD2 Antagonists | PTGDR2, PTGDR, PTGER2 | KCNA5 1912/4885KMT2A 3556/4885TSHR 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.