Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405975 | 0.81 | OPRL1 (0.54) | GPR84OPRM1FFAR1OPRL1OPRK1 | |
| SCHEMBL3409372 | 0.77 | OPRM1 (0.41) | OPRM1OGFRL1OPRL1OPRK1ALDH1A1 | |
| SCHEMBL4089692 | 0.75 | OPRM1 (0.39) | OPRM1OGFRL1OPRL1OPRK1MEN1 | |
| SCHEMBL3408763 | 0.72 | OPRL1 (0.44) | OPRM1OGFRL1CYP2D6SLC6A4OPRL1 | |
| SCHEMBL5164787 | 0.72 | OPRL1 (0.69) | OPRM1OPRL1ALDH1A1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5164262 | 0.71 | OPRL1 (0.68) | OPRM1OPRL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5164225 | 0.71 | OPRL1 (0.48) | OPRM1SLC6A2SLC6A4SLC6A3OPRL1 | |
| SCHEMBL5167089 | 0.71 | OPRL1 (0.48) | OPRM1SLC6A2SLC6A4SLC6A3OPRL1 | |
| SCHEMBL13503629 | 0.71 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRK1MEN1 | |
| SCHEMBL14064206 | 0.68 | NR3C1 (0.47) | GPR84FFAR1CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254864-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2014-05-14 | — | — | EP | claimed |
| CN-102015640-A | Substituted 4-aminocyclohexane derivatives for the treatment of pain | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | claimed |
| US-20090215725-A1 | Substituted 4-aminocyclohexane derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | claimed |
| EP-2254864-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2014-05-14 | — | — | EP | disclosed |
| CN-102015640-A | Substituted 4-aminocyclohexane derivatives for the treatment of pain | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | disclosed |
| US-20090215725-A1 | Substituted 4-aminocyclohexane derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215725-A1 | Substituted 4-aminocyclohexane derivatives | OPRL1, OPRD1, OPRK1 | GPR84 159/4885OPRM1 7/4885OGFRL1 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.