Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392531 | 0.88 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL2804263 | 0.88 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL18204421 | 0.84 | KDM4E (0.47) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL523320 | 0.83 | KDM4E (0.62) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL14645588 | 0.82 | EPHX2 (0.43) | KDM4EHSD17B10HDAC1HDAC6LMNA | |
| SCHEMBL2804881 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL16959889 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL30221008 | 0.80 | HTT (0.59) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL838252 | 0.80 | KDM4E (0.50) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL1482927 | 0.80 | HTT (0.59) | ALDH1A1KDM4EHSD17B10MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210130337-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | KING'S COLLEGE LONDON (GB) | 2021-05-06 | — | — | US | disclosed |
| CN-107207488-B | Bicyclic heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RAR) agonists | 伦敦皇家学院 | 2020-11-17 | — | — | CN | disclosed |
| US-10752616-B2 | Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists | KING'S COLLEGE LONDON (GB) | 2020-08-25 | — | — | US | disclosed |
| US-20200131165-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | KING'S COLLEGE LONDON (GB) | 2020-04-30 | — | — | US | disclosed |
| US-20190010146-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | KING'S COLLEGE LONDON (GB) | 2019-01-10 | — | — | US | disclosed |
| EP-2013201-B1 | HETEROCYCLIC GPCR AGONISTS | PROSIDION LTD (GB) | 2012-07-25 | — | — | EP | disclosed |
| US-20090325924-A1 | GPCR Agonists | PROSIDION LIMITED (GB) | 2009-12-31 | — | — | US | disclosed |
| US-20090221639-A1 | Heterocyclic GPCR Agonists | PROSIDION LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| EP-2013201-A1 | HETEROCYCLIC GPCR AGONISTS | Prosidion Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007116229-A1 | HETEROCYCLIC GPCR AGONISTS | PROSIDION LIMITED (GB) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130337-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | RARB, RARA, RXRB | ALDH1A1 253/4885KDM4E 3575/4885HSD17B10 674/4885 |
| US-20200131165-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | RARB, RARA, RXRB | ALDH1A1 253/4885KDM4E 3575/4885HSD17B10 674/4885 |
| US-20090325924-A1 | GPCR Agonists | GPR119, GCGR, GPR27 | ALDH1A1 1059/4885KDM4E 3925/4885HSD17B10 952/4885 |
| US-20190010146-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | RARB, RARA, RXRB | ALDH1A1 253/4885KDM4E 3599/4885HSD17B10 688/4885 |
| US-20090221639-A1 | Heterocyclic GPCR Agonists | GPR119, GCGR, GLP1R | ALDH1A1 1260/4885KDM4E 3078/4885HSD17B10 1120/4885 |
| US-10752616-B2 | Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists | RARB, RARA, RXRB | ALDH1A1 238/4885KDM4E 3621/4885HSD17B10 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.