Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17335561 | 1.00 | EPHX2 (0.58) | EPHX2MTNR1AMTNR1BSMN1; SMN2NPSR1 | |
| SCHEMBL10263607 | 1.00 | EPHX2 (0.58) | EPHX2MTNR1AMTNR1BSMN1; SMN2NPSR1 | |
| SCHEMBL256673 | 0.91 | — | — | |
| SCHEMBL11682924 | 0.91 | MTNR1A (0.50) | MTNR1AMTNR1BSMN1; SMN2NPSR1KMT2A | |
| Hydrochloric Acid SCHEMBL28162204 | 0.89 | — | — | |
| SCHEMBL25069845 | 0.88 | MTNR1A (0.46) | EPHX2MTNR1AMTNR1BSMN1; SMN2KMT2A | |
| SCHEMBL20688436 | 0.88 | MTNR1A (0.46) | EPHX2MTNR1AMTNR1BSMN1; SMN2KMT2A | |
| SCHEMBL20696995 | 0.88 | MTNR1A (0.46) | EPHX2MTNR1AMTNR1BSMN1; SMN2KMT2A | |
| SCHEMBL11822035 | 0.83 | EPHX2 (0.54) | EPHX2MTNR1AMTNR1BSMN1; SMN2KMT2A | |
| SCHEMBL13573015 | 0.83 | EPHX2 (0.54) | EPHX2MTNR1AMTNR1BSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232471-B | Preparation method of pramipexole dihydrochloride | 安徽省庆云医药股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |
| US-9884814-B2 | Acylguanidines for treating osteoarthritis | MERCK PATENT GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| US-20150361037-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20090062549-A1 | PROCESS FOR THE PREPARATION OF PRAMIPEXOLE AND NEW ANHYDROUS FORMS OF ITS DIHYDROCHLORIDE | RANBAXY LABORATORIES LIMITED (IN) | 2009-03-05 | — | — | US | disclosed |
| WO-2006117614-A1 | PROCESS FOR THE PREPARATION OF PRAMIPEXOLE AND NEW ANHYDROUS FORMS OF ITS DIHYDROCHLORIDE | RANBAXY LABORATORIES LIMITED (IN) | 2006-11-09 | — | — | WO | disclosed |
| EP-1318987-B1 | PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR | SYNTHON BV (NL) | 2005-08-10 | — | — | EP | disclosed |
| US-6727367-B2 | QUATERNIZING PRAMIPEXOLE INTO OPTICAL ISOMERS VIA REACTING MONOBASIC ACID ADDITION SALT WITH OPTICALLY ACTIVE ACID FORMING DIASTEREOMERIC MIXED SALTS AND PRECIPITATING FROM SOLVENT TO FORM SEPARATED DIASTEREOMERS | SYNTHON BV (NL) | 2004-04-27 | — | — | US | disclosed |
| US-20040068119-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | POSPISILIK KAREL (CZ) | 2004-04-08 | — | — | US | disclosed |
| EP-1318987-A1 | PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR | Synthon B.V. (NL) | 2003-06-18 | — | — | EP | disclosed |
| US-20020103240-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | SYNTHON IP INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2002022591-A1 | PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR | SYNTHON B.V. (NL) | 2002-03-21 | — | — | WO | disclosed |
| US-3960945-A | 4-[-(Alkoxy or polyhaloalkoxy)-benzamido]cyclohexanones | STERLING DRUG INC. (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068119-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | NOTUM, SLC5A6, WEE2 | EPHX2 1771/4885MTNR1A 1645/4885MTNR1B 298/4885 |
| US-20020103240-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | NOTUM, SLC5A6, WEE2 | EPHX2 1771/4885MTNR1A 1645/4885MTNR1B 298/4885 |
| US-20090062549-A1 | PROCESS FOR THE PREPARATION OF PRAMIPEXOLE AND NEW ANHYDROUS FORMS OF ITS DIHYDROCHLORIDE | CYP4A11, QDPR, CYP2D6 | EPHX2 147/4885MTNR1A 343/4885MTNR1B 69/4885 |
| US-20150361037-A1 | ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS | CTSG, CTSD, CTSB | EPHX2 2649/4885MTNR1A 348/4885MTNR1B 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.