Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098980 | 0.88 | AKR1C3 (0.46) | SMN1; SMN2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL4102938 | 0.78 | L3MBTL1 (0.68) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL6101952 | 0.75 | RAB9A (0.66) | NPC1RAB9AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL5698524 | 0.73 | AKR1C3 (0.49) | RAB9AL3MBTL1MAPTSMN1; SMN2AKR1C3 | |
| SCHEMBL5698531 | 0.73 | AKR1C3 (0.49) | RAB9AL3MBTL1MAPTSMN1; SMN2AKR1C3 | |
| SCHEMBL1150860 | 0.72 | LTA4H (0.47) | AKR1C3AKR1C2AKR1C1ALDH1A1HTT | |
| SCHEMBL6203734 | 0.71 | ALDH1A1 (0.55) | NPC1RAB9AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL7720768 | 0.69 | NPC1 (0.56) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL7720766 | 0.69 | NPC1 (0.56) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL6283076 | 0.69 | NAMPT (0.54) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |