Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133326 | 0.99 | CA12 (0.57) | CA12CA1CA2CA9ALOX5 | |
| SCHEMBL4099224 | 0.97 | CA12 (0.56) | CA12CA1CA2CA9ALOX5 | |
| SCHEMBL4102815 | 0.97 | CA12 (0.56) | CA12CA1CA2CA9ALOX5 | |
| SCHEMBL4103989 | 0.97 | CA12 (0.56) | CA12CA1CA2CA9ALOX5 | |
| SCHEMBL7601194 | 0.82 | ALDH1A1 (0.48) | CA12CA1CA2CA9ALOX5 | |
| SCHEMBL619394 | 0.80 | ALDH1A1 (0.57) | CA1CA2SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL30460084 | 0.80 | ALDH1A1 (0.57) | CA1CA2SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27811568 | 0.79 | ALDH1A1 (0.53) | CA1CA2SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL9243462 | 0.79 | ALDH1A1 (0.56) | CA1CA2SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27730499 | 0.77 | MDM2 (0.54) | ALOX5SMN1; SMN2CES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090120545-A1 | Infra-Red Decoy Flare | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETEN-SCHAPPELIJK ONDERZOEK TNO (NL) | 2009-05-14 | — | — | US | claimed |
| EP-1904421-A2 | AN INFRA-RED DECOY FLARE | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO (NL) | 2008-04-02 | — | — | EP | claimed |
| WO-2007004871-A2 | AN INFRA-RED DECOY FLARE | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2007-01-11 | — | — | WO | claimed |
| US-20090120545-A1 | Infra-Red Decoy Flare | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETEN-SCHAPPELIJK ONDERZOEK TNO (NL) | 2009-05-14 | — | — | US | disclosed |
| EP-1904421-A2 | AN INFRA-RED DECOY FLARE | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO (NL) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004871-A2 | AN INFRA-RED DECOY FLARE | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2007-01-11 | — | — | WO | disclosed |