Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16701755 | 0.98 | MAPT (0.45) | MAPTGPR35TACR1P2RX1LMNA | |
| SCHEMBL4099566 | 0.86 | MAPT (0.51) | MAPTGPR35TACR1P2RX1LMNA | |
| SCHEMBL11884384 | 0.85 | MAPT (0.52) | MAPTGPR35TACR1P2RX1LMNA | |
| SCHEMBL14458130 | 0.85 | MAPT (0.55) | MAPTGPR35TACR1P2RX1LMNA | |
| SCHEMBL4100624 | 0.83 | ALDH1A1 (0.55) | MAPTLMNACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL5598006 | 0.83 | MAPT (0.53) | MAPTGPR35TACR1P2RX1LMNA | |
| Hydrochloric Acid SCHEMBL9666367 | 0.82 | ALDH1A1 (0.54) | MAPTLMNACA12CA1CA2 | |
| SCHEMBL4099321 | 0.82 | KIF11 (0.53) | MAPTCA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL16701795 | 0.81 | KIF11 (0.51) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL11814323 | 0.81 | MAPT (0.57) | MAPTGPR35TACR1P2RX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751833-B2 | Antimicrobial biguanide metal complexes | SMITH & NEPHEW PLC (GB) | 2017-09-05 | — | — | US | disclosed |
| EP-1902059-B1 | ANTIMICROBIAL BIGUANIDE METAL COMPLEXES | SMITH & NEPHEW (GB) | 2016-12-21 | — | — | EP | disclosed |
| CN-101253182-B | Antimicrobial biguanide metal complexes | SMITH & NEPHEW | 2015-05-06 | — | — | CN | disclosed |
| US-20090194124-A1 | Hair Shaping Kit and Process Comprising at Least One Non-Hydroxide Imine | MALLE GERARD | 2009-08-06 | — | — | US | disclosed |
| US-20090139537-A1 | HAIR RELAXING COMPOSITION COMPRISING AT LEAST ONE NON-HYDROXIDE IMINE | L'OREAL S.A. | 2009-06-04 | — | — | US | disclosed |
| US-20090123513-A1 | Antimicrobial Biguanide Metal Complexes | SMITH & NEPHEW PLC (GB) | 2009-05-14 | — | — | US | disclosed |
| EP-1902059-A1 | ANTIMICROBIAL BIGUANIDE METAL COMPLEXES | Smith & Nephew, PLC (GB) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007000590-A1 | ANTIMICROBIAL BIGUANIDE METAL COMPLEXES | SMITH & NEPHEW PLC (GB) | 2007-01-04 | — | — | WO | disclosed |
| US-20050136017-A1 | Cosmetic containing an imine reactive with the cystines of keratin fibers via a beta-elimination reaction to produce dehydroalanine and lead to formation of lanthionine in a medium free of polyhydroxylated alkane; guanidine and/or amidine imines such as dimethylguanidine; noncaustic for use on hair, skin | L'OREAL S.A. (FR) | 2005-06-23 | — | — | US | disclosed |
| US-20050129645-A1 | Hair shaping composition comprising at least one non-hydroxide imine | L'OREAL | 2005-06-16 | — | — | US | disclosed |
| EP-1532963-A1 | Composition for straightening the hair comprising at least one imine not being an hydroxide | L'OREAL (FR) | 2005-05-25 | — | — | EP | disclosed |
| EP-1532960-A1 | Hair styling composition containing a non-hydroxide imine | L'OREAL (FR) | 2005-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090123513-A1 | Antimicrobial Biguanide Metal Complexes | GLMN, SOD1, MB | MAPT 4032/4885GPR35 2882/4885TACR1 2832/4885 |
| US-20090139537-A1 | HAIR RELAXING COMPOSITION COMPRISING AT LEAST ONE NON-HYDROXIDE IMINE | KRT18, INMT, INHA | MAPT 2845/4885GPR35 286/4885TACR1 1560/4885 |
| US-20090194124-A1 | Hair Shaping Kit and Process Comprising at Least One Non-Hydroxide Imine | KRT18, KIT, PRDM7 | MAPT 2382/4885GPR35 2900/4885TACR1 3652/4885 |
| US-20050129645-A1 | Hair shaping composition comprising at least one non-hydroxide imine | KRT18, INHA, H1-5 | MAPT 2407/4885GPR35 2719/4885TACR1 3666/4885 |
| US-20050136017-A1 | Cosmetic containing an imine reactive with the cystines of keratin fibers via a beta-elimination reaction to produce dehydroalanine and lead to formation of lanthionine in a medium free of polyhydroxylated alkane; guanidine and/or amidine imines such as dimethylguanidine; noncaustic for use on hair, skin | BHMT, KRT18, INMT | MAPT 3332/4885GPR35 447/4885TACR1 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.