Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1678485 | 0.85 | AKR1B1 (0.48) | CYP3A4TSHRPIK3CAESR1KCNH2 | |
| SCHEMBL339508 | 0.82 | P2RX7 (0.44) | ESR1ALDH1A1GAANPSR1ICMT | |
| SCHEMBL28176483 | 0.82 | HTT (0.37) | CYP3A4TSHRPIK3CAESR1KCNH2 | |
| SCHEMBL5210376 | 0.81 | GAA (0.50) | TSHRALDH1A1GAANPSR1ICMT | |
| Hydrochloric Acid SCHEMBL14167164 | 0.81 | P2RX7 (0.43) | TSHRESR1ALDH1A1GAANPSR1 | |
| SCHEMBL27528089 | 0.80 | MTNR1A (0.47) | CYP3A4TSHRPIK3CAESR1KCNH2 | |
| SCHEMBL8524830 | 0.80 | ESR1 (0.47) | CYP3A4TSHRPIK3CAESR1KCNH2 | |
| SCHEMBL1817738 | 0.80 | GAA (0.41) | GAANPSR1FDPSCA2CD44 | |
| SCHEMBL1039164 | 0.79 | FDPS (0.48) | CYP3A4TSHRALDH1A1GAANPSR1 | |
| SCHEMBL13750888 | 0.79 | GAA (0.38) | GAANPSR1ICMTHTTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318761-B2 | Substituted arylsulfonamides as antiviral agents | AICURIS GMBH & CO. KG (DE) | 2012-11-27 | — | — | US | disclosed |
| EP-1991529-B1 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS | AICURIS GMBH & CO KG (DE) | 2009-12-09 | — | — | EP | disclosed |
| US-20090176842-A1 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2009-07-09 | — | — | US | disclosed |
| EP-1991529-A1 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS | AiCuris GmbH & Co. KG (DE) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007101573-A1 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS | AICURIS GMBH & CO. KG (DE) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176842-A1 | SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS | TPMT, ARSA, TYMP | CYP3A4 261/4885TSHR 3623/4885PIK3CA 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.