Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IAPP | P10997 | 3/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3907285 | 0.82 | AKR1B1 (0.67) | GAAAKR1B1TRPA1ATMMAPT | |
| SCHEMBL339508 | 0.82 | P2RX7 (0.44) | GAANPSR1TRPA1ATMMAPT | |
| SCHEMBL2545614 | 0.82 | IAPP (0.50) | GAAAKR1B1TRPA1ATMMAPT | |
| SCHEMBL6405069 | 0.82 | P4HB (0.43) | GAANPSR1AKR1B1MAPTMEN1 | |
| SCHEMBL4100411 | 0.81 | CYP3A4 (0.48) | GAANPSR1CA2GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL14167164 | 0.81 | P2RX7 (0.43) | GAANPSR1TRPA1ATMMAPT | |
| SCHEMBL11029713 | 0.80 | GAA (0.53) | GAANPSR1AKR1B1IAPPCA2 | |
| SCHEMBL4655209 | 0.79 | AKR1B1 (0.68) | GAANPSR1AKR1B1MAPTCA2 | |
| SCHEMBL299227 | 0.79 | AKR1B1 (0.68) | GAANPSR1AKR1B1MAPTCA2 | |
| SCHEMBL13750888 | 0.79 | GAA (0.38) | GAANPSR1CA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-B1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LTD (GB) | 2007-09-05 | — | — | EP | claimed |
| EP-1620087-A1 | AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES, LTD. (IN) | 2006-02-01 | — | — | EP | claimed |
| WO-2004089364-A1 | AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-10-21 | — | — | WO | claimed |