Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598841 | 0.83 | ADRB2 (0.38) | ADRB2ADRB1AOC3F2RL1 | |
| SCHEMBL17235787 | 0.80 | DPP4 (0.37) | MAPK1DPP4IGF1RMEN1KMT2A | |
| SCHEMBL907710 | 0.78 | EPHX2 (0.38) | PTGDR2AOC3 | |
| SCHEMBL5930989 | 0.77 | SLC6A2 (0.40) | MEN1KMT2AADRB2ALDH1A1MAPT | |
| SCHEMBL6580186 | 0.76 | AOC3 (0.36) | MAPK1HSD17B10DPP4IGF1RMEN1 | |
| SCHEMBL8203438 | 0.76 | SLC6A4 (0.41) | MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL4493580 | 0.73 | DPP4 (0.44) | MAPK1DPP4IGF1RMEN1KMT2A | |
| SCHEMBL5518530 | 0.73 | IGF1R (0.46) | MAPK1DPP4IGF1RMEN1KMT2A | |
| SCHEMBL6673940 | 0.73 | PTGDR2 (0.40) | MEN1KMT2APTGDR2ALDH1A1MAPT | |
| SCHEMBL11867787 | 0.73 | HDAC3 (0.36) | DPP4IGF1RKMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116522-A1 | Process for the preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans | JUBILANT ORGANOSYS, LTD. (IN) | 2006-06-01 | — | — | US | claimed |
| US-20060009515-A1 | Process and intermediates for preparing escitalopram | TORCAN CHEMICAL LTD (CA) | 2006-01-12 | — | — | US | claimed |
| EP-1495013-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL Ltd (CA) | 2005-01-12 | — | — | EP | claimed |
| WO-2004020425-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURANS | JUBILANT ORGANOSYS LTD. (IN) | 2004-03-11 | — | — | WO | claimed |
| WO-2003087081-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL LTD. (CA) | 2003-10-23 | — | — | WO | claimed |
| EP-2017271-A1 | Process for the preparation of escitalopram | Aurobindo Pharma Limited (IN) | 2009-01-21 | — | — | EP | disclosed |
| US-20090018351-A1 | PREPARATION OF ESCITALOPRAM | DR. REDDY'S LABORATORIES, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-7411077-B2 | Process for the preparation of a cyano-isobenzofuran | ADORKEN TECHNOLOGY SPA (IT) | 2008-08-12 | — | — | US | disclosed |
| US-20060183925-A1 | Process for the preparation of a cyano-isobenzofuran | ADORKEM TECHNOLOGY SPA | 2006-08-17 | — | — | US | disclosed |
| US-20060116522-A1 | Process for the preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans | JUBILANT ORGANOSYS, LTD. (IN) | 2006-06-01 | — | — | US | disclosed |
| US-20060009515-A1 | Process and intermediates for preparing escitalopram | TORCAN CHEMICAL LTD (CA) | 2006-01-12 | — | — | US | disclosed |
| US-20060009515-A1 | Process and intermediates for preparing escitalopram | TORCAN CHEMICAL LTD (CA) | 2006-01-12 | — | — | US | disclosed |
| EP-1495013-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL Ltd (CA) | 2005-01-12 | — | — | EP | disclosed |
| EP-1495013-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL Ltd (CA) | 2005-01-12 | — | — | EP | disclosed |
| WO-2004080988-A1 | PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN | ADORKEM TECHNOLOGY SPA (IT) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004054974-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |
| WO-2004020425-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURANS | JUBILANT ORGANOSYS LTD. (IN) | 2004-03-11 | — | — | WO | disclosed |
| WO-2003087081-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL LTD. (CA) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003087081-A1 | PROCESS AND INTERMEDIATES FOR PREPARING ESCITALOPRAM | TORCAN CHEMICAL LTD. (CA) | 2003-10-23 | — | — | WO | disclosed |
| US-4136193-A | ANTI-DEPRESSIVE SUBSTITUTED 1-DIMETHYLAMINOPROPYL-1-PHENYL PHTHALANS | KEFALAS A/S (DK) | 1979-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116522-A1 | Process for the preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans | CYP4F2, CYP2F1, CYP4F3 | MAPK1 2554/4885HSD17B10 608/4885DPP4 1302/4885 |
| US-20060183925-A1 | Process for the preparation of a cyano-isobenzofuran | HTR1F, CYP4F12, CYP4F3 | MAPK1 3557/4885HSD17B10 1266/4885DPP4 1415/4885 |
| US-20090018351-A1 | PREPARATION OF ESCITALOPRAM | HTR4, SLC6A4, HTR5A | MAPK1 2983/4885HSD17B10 888/4885DPP4 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.