Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814244 | 0.82 | FNTA (0.39) | TOP2ATOP2BCYP19A1MAOAMAOB | |
| SCHEMBL7598841 | 0.79 | ADRB2 (0.38) | PTGS1AOC3 | |
| SCHEMBL4085361 | 0.79 | TOP2A (0.40) | EPHX2SCN9ATOP2ATOP2BS1PR3 | |
| SCHEMBL27702058 | 0.78 | AOC3 (0.36) | EPHX2SCN9AS1PR3CYP19A1AOC3 | |
| SCHEMBL3986098 | 0.78 | AOC3 (0.36) | EPHX2SCN9AS1PR3CYP19A1AOC3 | |
| SCHEMBL27836477 | 0.78 | EPHX2 (0.38) | EPHX2SCN9ACYP19A1PTGDR2AOC3 | |
| SCHEMBL2337792 | 0.78 | EPHX2 (0.38) | EPHX2SCN9ACYP19A1PTGDR2AOC3 | |
| SCHEMBL27836479 | 0.78 | EPHX2 (0.38) | EPHX2SCN9ACYP19A1PTGDR2AOC3 | |
| SCHEMBL27816963 | 0.78 | AOC3 (0.36) | EPHX2SCN9AS1PR3CYP19A1AOC3 | |
| SCHEMBL4100718 | 0.78 | MAPK1 (0.41) | PTGDR2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411077-B2 | Process for the preparation of a cyano-isobenzofuran | ADORKEN TECHNOLOGY SPA (IT) | 2008-08-12 | — | — | US | claimed |
| US-20060183925-A1 | Process for the preparation of a cyano-isobenzofuran | ADORKEM TECHNOLOGY SPA | 2006-08-17 | — | — | US | claimed |
| US-20060116522-A1 | Process for the preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans | JUBILANT ORGANOSYS, LTD. (IN) | 2006-06-01 | — | — | US | claimed |
| CN-1761658-A | Process for the preparation of a cyano-isobenzofuran | ADORKEM TECHNOLOGY SPA (IT) | 2006-04-19 | — | — | CN | claimed |
| EP-1601662-A1 | PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN | Adorkem Technology SpA (IT) | 2005-12-07 | — | — | EP | claimed |
| WO-2004080988-A1 | PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN | ADORKEM TECHNOLOGY SPA (IT) | 2004-09-23 | — | — | WO | claimed |
| EP-1228056-B1 | METHOD FOR THE PREPARATION OF CITALOPRAM | LUNDBECK & CO AS H (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2004020425-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURANS | JUBILANT ORGANOSYS LTD. (IN) | 2004-03-11 | — | — | WO | claimed |
| EP-1228056-A2 | METHOD FOR THE PREPARATION OF CITALOPRAM | H. LUNDBECK A/S (DK) | 2002-08-07 | — | — | EP | claimed |
| US-20020035277-A1 | Method for the preparation of citalopram | H. LUNDBECK A/S (DK) | 2002-03-21 | — | — | US | claimed |
| WO-2000012044-A2 | METHOD FOR THE PREPARATION OF CITALOPRAM | H. LUNDBECK A/S (DK) | 2000-03-09 | — | — | WO | claimed |
| US-11845710-B2 | Method for continuously preparing citalopram diol | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2023-12-19 | — | — | US | disclosed |
| EP-3896057-B1 | METHOD FOR CONTINUOUSLY PREPARING CITALOPRAM DIOL | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2023-05-31 | — | — | EP | disclosed |
| US-20220024860-A1 | METHOD FOR CONTINUOUSLY PREPARING CITALOPRAM DIOL | SHANGHAI AOBO PHARMTECH, INC., LTD. (CN) | 2022-01-27 | — | — | US | disclosed |
| EP-3896057-A1 | METHOD FOR CONTINUOUSLY PREPARING 5-CITALOPRAM DIOL | Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) | 2021-10-20 | — | — | EP | disclosed |
| US-20020035277-A1 | Method for the preparation of citalopram | H. LUNDBECK A/S (DK) | 2002-03-21 | — | — | US | disclosed |
| US-6291689-B1 | CYCLIZING 4-CYANO-2-HYDROXYMETHYLPHENYL)(4-FLUOROPHENYL)METHANOL TO FORM 1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE; ALKYLATING TO FORM CITALOPRAM | H. LUNDBECK A/S (DK) | 2001-09-18 | — | — | US | disclosed |
| EP-1032566-A2 | METHOD FOR THE PREPARATION OF CITALOPRAM | H. LUNDBECK A/S (DK) | 2000-09-06 | — | — | EP | disclosed |
| WO-2000012044-A2 | METHOD FOR THE PREPARATION OF CITALOPRAM | H. LUNDBECK A/S (DK) | 2000-03-09 | — | — | WO | disclosed |
| WO-1998019511-A2 | METHOD FOR THE PREPARATION OF CITALOPRAM | H. LUNDBECK A/S (DK) | 1998-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035277-A1 | Method for the preparation of citalopram | HTR6, HTR1A, HTR1F | EPHX2 4049/4885SCN9A 1569/4885TOP2A 331/4885 |
| US-20220024860-A1 | METHOD FOR CONTINUOUSLY PREPARING CITALOPRAM DIOL | GRHPR, TPH2, SLC6A4 | EPHX2 1144/4885SCN9A 4390/4885TOP2A 723/4885 |
| US-11845710-B2 | Method for continuously preparing citalopram diol | GRHPR, TPH2, SLC6A4 | EPHX2 1144/4885SCN9A 4390/4885TOP2A 723/4885 |
| US-20060116522-A1 | Process for the preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans | CYP4F2, CYP2F1, CYP4F3 | EPHX2 2649/4885SCN9A 3220/4885TOP2A 570/4885 |
| US-20060183925-A1 | Process for the preparation of a cyano-isobenzofuran | HTR1F, CYP4F12, CYP4F3 | EPHX2 4176/4885SCN9A 2598/4885TOP2A 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.