Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741911 | 1.00 | CTSS (0.47) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL14974209 | 0.86 | HDAC4 (0.43) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL14974206 | 0.86 | HDAC4 (0.43) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL742779 | 0.86 | CTSS (0.50) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL3725538 | 0.86 | CTSS (0.50) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL500438 | 0.84 | HDAC4 (0.44) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL3687446 | 0.84 | HDAC4 (0.44) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL861583 | 0.84 | HDAC4 (0.44) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL30396703 | 0.81 | HDAC4 (0.37) | CTSSCTSKHDAC4HDAC1HDAC6 | |
| SCHEMBL30170256 | 0.80 | CTSL (0.38) | HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101969973-B | Inhibitors of cathepsin B | VIROBAY INC | 2015-07-22 | — | — | CN | disclosed |
| US-8211897-B2 | Inhibitors of cathepsin B | VIROBAY, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| CN-101969973-A | Inhibitors of cathepsin b | VIROBAY INC | 2011-02-09 | — | — | CN | disclosed |
| US-20090203629-A1 | INHIBITORS OF CATHEPSIN B | VIROBAY, INC. (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203629-A1 | INHIBITORS OF CATHEPSIN B | CTSB, CSTB, CTSF | CTSS 4/4885CTSK 9/4885HDAC4 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.