Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R38 | P59533 | 3/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | TYR | P14679 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340780 | 0.97 | TAS2R38 (1.00) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| SCHEMBL31110551 | 0.95 | TAS2R38 (0.95) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| Phosphonic Acid SCHEMBL9435620 | 0.87 | TAS2R38 (0.79) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| SCHEMBL14511451 | 0.84 | TAS2R38 (0.75) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| SCHEMBL201794 | 0.79 | ALDH1A1 (0.67) | TAS2R38ALDH1A1CYP3A4GAAKMT2A | |
| Acrylamide SCHEMBL11027613 | 0.79 | TAS2R38 (0.66) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| Phenylthiourea SCHEMBL42753 | 0.77 | ALDH1A1 (1.00) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| Phenylthiourea SCHEMBL11820844 | 0.77 | ALDH1A1 (1.00) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| Phenylthiourea SCHEMBL7814239 | 0.76 | ALDH1A1 (0.86) | TAS2R38HSD17B10ALDH1A1TP53TYR | |
| SCHEMBL28051724 | 0.76 | TAS2R38 (0.63) | TAS2R38HSD17B10ALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265593-B1 | NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF | AETERNA ZENTARIS GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| EP-2604594-A1 | 1,2,4-Triazole derivatives as ghrelin analogue ligands of GHS receptors | Æterna Zentaris GmbH (DE) | 2013-06-19 | — | — | EP | disclosed |
| US-20090239877-A1 | NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF | AETERNA ZENTARIS GMBH (DE) | 2009-09-24 | — | — | US | disclosed |
| EP-2103602-A1 | Novel 1,2,4-triazole derivatives and process of manufacturing thereof | AEterna Zentaris GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239877-A1 | NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF | CYP3A4, CYP4B1, CYP1B1 | TAS2R38 338/4885HSD17B10 431/4885ALDH1A1 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.