Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18133061 | 0.92 | RCE1 (0.49) | TRPA1RCE1TSHRHTTALDH1A1 | |
| SCHEMBL51132 | 0.92 | RCE1 (0.49) | TRPA1RCE1TSHRHTTALDH1A1 | |
| Ethylene Glycol SCHEMBL28253374 | 0.90 | RCE1 (0.45) | TRPA1RCE1TSHRHTTALDH1A1 | |
| Potassium SCHEMBL31590372 | 0.90 | RCE1 (0.47) | TRPA1RCE1TSHRHTTALDH1A1 | |
| SCHEMBL6964566 | 0.90 | RCE1 (0.47) | TRPA1RCE1TSHRHTTALDH1A1 | |
| Propylene Glycol SCHEMBL5533372 | 0.84 | TSHR (0.62) | TRPA1TSHRHTTALDH1A1LMNA | |
| Propylene Glycol SCHEMBL7058411 | 0.82 | TRPA1 (0.47) | TRPA1RCE1TSHRHTTALDH1A1 | |
| SCHEMBL9013134 | 0.81 | HPGD (0.45) | RCE1TSHRHTTALDH1A1LMNA | |
| SCHEMBL3813606 | 0.80 | TRPA1 (0.48) | TRPA1RCE1TSHRHTTALDH1A1 | |
| SCHEMBL647500 | 0.80 | TRPA1 (0.48) | TRPA1RCE1TSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1676562-B2 | Composition for the hair containing uv filters | KAO GERMANY GMBH (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-1676562-B1 | Composition for the hair containing uv filters | KAO GERMANY GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20090104137-A1 | COSMETIC COMPOSITION | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1676562-A1 | Composition for the hair containing uv filters | KPSS-Kao Professional Salon Services GmbH (DE) | 2006-07-05 | — | — | EP | disclosed |
| US-20060134030-A1 | Cosmetic composition | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060134030-A1 | Cosmetic composition | CUTA, TRPC5, H1-5 | TRPA1 6/4885RCE1 4595/4885TSHR 3675/4885 |
| US-20090104137-A1 | COSMETIC COMPOSITION | CUTA, TRPC5, H1-5 | TRPA1 6/4885RCE1 4595/4885TSHR 3675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.