Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PPM1B | O75688 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069485 | 0.89 | POLB (0.45) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL411551 | 0.87 | KMT2A (0.55) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL2169224 | 0.77 | ALDH1A1 (0.70) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL9064640 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL411110 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL14991107 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL29763164 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL411173 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL441970 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL7285516 | 0.73 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716314-B2 | Isotopologues of thalidomide | CELGENE CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CELGENE CORPORATION | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CDK4, FKBP8, FKBP1A | ALDH1A1 1659/4885MAPK1 3339/4885KDM4E 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.