Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412892 | 0.88 | HSP90AA1 (0.38) | CYP19A1ALDH1A1GAAALOX15P2RX3 | |
| SCHEMBL412798 | 0.80 | CYP19A1 (0.61) | CYP19A1ALDH1A1SETD7MEN1LMNA | |
| SCHEMBL14214714 | 0.77 | AVPR2 (0.47) | EGFRNOX4ALDH1A1HSD17B10P2RX3 | |
| SCHEMBL20073958 | 0.75 | MAPT (0.41) | EGFRNOX4ALDH1A1P2RX3MEN1 | |
| SCHEMBL18930912 | 0.74 | AVPR2 (0.49) | EGFRALDH1A1P2RX3MEN1LMNA | |
| SCHEMBL410105 | 0.73 | NOX4 (0.36) | EGFRCYP19A1NOX4ALDH1A1GAA | |
| SCHEMBL411957 | 0.72 | CAMKK2 (0.35) | EGFRCYP19A1NOX4ALDH1A1GAA | |
| SCHEMBL2341546 | 0.72 | ABL1 (0.49) | ALDH1A1GAAHSD17B10P2RX3MEN1 | |
| SCHEMBL722270 | 0.71 | PTGER4 (0.52) | EGFRGAAMEN1LMNAKMT2A | |
| SCHEMBL411958 | 0.71 | HSP90AA1 (0.53) | CYP19A1ALDH1A1SETD7MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |