Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412797 | 0.84 | ALDH1A1 (0.38) | NOX4ALDH1A1TDP1EGFRRGS12 | |
| SCHEMBL411957 | 0.81 | CAMKK2 (0.35) | NOX4ALDH1A1TDP1EGFRRGS12 | |
| SCHEMBL411652 | 0.73 | KDM4C (0.34) | ALDH1A1MAPTKDM4CMAOAMAOB | |
| SCHEMBL411651 | 0.73 | EGFR (0.43) | NOX4ALDH1A1EGFRMAPTGAA | |
| SCHEMBL414360 | 0.73 | EPHX2 (0.38) | ALDH1A1EGFRMAPTEPHX2 | |
| SCHEMBL9252842 | 0.72 | CA12 (0.40) | NOX4ALDH1A1TDP1EGFRRGS12 | |
| SCHEMBL409990 | 0.72 | EGFR (0.71) | NOX4ALDH1A1TDP1EGFRRGS12 | |
| SCHEMBL410106 | 0.72 | CYP19A1 (0.47) | ALDH1A1EGFRMAPTCYP19A1 | |
| SCHEMBL414269 | 0.72 | EGFR (0.38) | NOX4ALDH1A1TDP1EGFRRGS12 | |
| SCHEMBL15168424 | 0.65 | CYP1A2 (0.51) | MAPTNR1H4GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |