Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996853 | 0.84 | GAA (0.42) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL4131950 | 0.82 | GAA (0.41) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL4125332 | 0.82 | PDE5A (0.46) | GAAALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4123921 | 0.75 | PDE5A (0.42) | — | |
| SCHEMBL4142307 | 0.73 | PDE5A (0.47) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL4136563 | 0.69 | PDE5A (0.43) | GAAALDH1A1KDM4EHPGDPDE9A | |
| SCHEMBL8041296 | 0.67 | PDE5A (0.48) | ALDH1A1HSD17B10HPGDMAPK1PDE1A | |
| SCHEMBL4126045 | 0.66 | PDE5A (0.41) | — | |
| SCHEMBL3997198 | 0.65 | ALDH1A1 (0.37) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL4132815 | 0.65 | KDM4E (0.41) | ALDH1A1KDM4ESMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |