Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410105 | 0.84 | NOX4 (0.36) | ALDH1A1TDP1MAPTGAANOX4 | |
| SCHEMBL411957 | 0.83 | CAMKK2 (0.35) | ALDH1A1TDP1MAPTGAANOX4 | |
| SCHEMBL413750 | 0.77 | CYP19A1 (0.63) | ALDH1A1TDP1MAPTGAAKDM4E | |
| SCHEMBL411652 | 0.75 | KDM4C (0.34) | ALDH1A1MAPTKDM4EBCL2L1MCL1 | |
| SCHEMBL411651 | 0.75 | EGFR (0.43) | ALDH1A1MAPTGAANOX4EGFR | |
| SCHEMBL414360 | 0.75 | EPHX2 (0.38) | ALDH1A1MAPTKDM4EEGFRSMN1; SMN2 | |
| SCHEMBL414269 | 0.74 | EGFR (0.38) | ALDH1A1TDP1MAPTNOX4RGS12 | |
| SCHEMBL28414899 | 0.72 | PLK1 (0.48) | ALDH1A1MAPTNR1H4BCL2L1MCL1 | |
| SCHEMBL410106 | 0.71 | CYP19A1 (0.47) | ALDH1A1MAPTEGFRPOLBCYP19A1 | |
| SCHEMBL1705430 | 0.70 | EGFR (0.75) | ALDH1A1TDP1MAPTNOX4RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |