Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | TSPO | P30536 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580316 | 0.90 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1KDM4EMAPK1HTT | |
| SCHEMBL4580656 | 0.88 | KDM4E (0.36) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL4119831 | 0.85 | KDM4E (0.30) | ALDH1A1KDM4EUSP2HPGD | |
| SCHEMBL4104812 | 0.84 | TSPO (0.39) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3988525 | 0.83 | KDM4E (0.40) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL4119752 | 0.81 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1KDM4EMAPK1HTT | |
| SCHEMBL4102580 | 0.80 | KDM4E (0.38) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3985323 | 0.78 | KDM4E (0.39) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3985510 | 0.77 | TSPO (0.40) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3988517 | 0.76 | ALDH1A1 (0.36) | ALDH1A1KDM4EMAPK1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802300-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1802300-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044232-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |