Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119828 | 0.90 | L3MBTL1 (0.32) | L3MBTL1ALDH1A1KDM4EMAPK1HTT | |
| SCHEMBL4119752 | 0.88 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1KDM4EMAPK1HTT | |
| SCHEMBL4110311 | 0.82 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1KDM4EMAPK1HTT | |
| SCHEMBL5199093 | 0.79 | TSPO (0.52) | L3MBTL1DYRK1ATSPO | |
| SCHEMBL3988525 | 0.79 | KDM4E (0.40) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3985510 | 0.78 | TSPO (0.40) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL3985323 | 0.78 | KDM4E (0.39) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL4117732 | 0.78 | AKR1B1 (0.47) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL4103872 | 0.77 | KDM4E (0.37) | ALDH1A1KDM4EMAPK1HTTHSD17B10 | |
| SCHEMBL4106665 | 0.77 | TSPO (0.39) | ALDH1A1KDM4EMAPK1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080097108-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080097108-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNH2, KCNN1, KCNH3 | L3MBTL1 4754/4885ALDH1A1 979/4885KDM4E 1326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.