Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 5/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104812 | 0.94 | TSPO (0.39) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL3988525 | 0.94 | KDM4E (0.40) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL4102580 | 0.91 | KDM4E (0.38) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL3985323 | 0.89 | KDM4E (0.39) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL4119828 | 0.88 | L3MBTL1 (0.32) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL3988517 | 0.86 | ALDH1A1 (0.36) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL3985510 | 0.85 | TSPO (0.40) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL4114936 | 0.84 | PDE5A (0.38) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL4103872 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1MAPK1HTTHSD17B10 | |
| SCHEMBL4102208 | 0.82 | HSD17B10 (0.44) | KDM4EALDH1A1MAPK1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080097108-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080097108-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNH2, KCNN1, KCNH3 | KDM4E 1326/4885ALDH1A1 979/4885MAPK1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.