Dimethylamine

Dimethylamine

SCHEMBL4121737

CNC.Cc1c(OCc2ccccc2C#N)ccc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc12

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 9/20 0.39
CSF1R P07333 2/20 0.39
KDR P35968 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PKM P14618 1/20 0.38
CETP P11597 2/20 0.37
ACHE P22303 1/20 0.37
TBK1 Q9UHD2 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
SLC6A4 P31645 1/20 0.36
EGLN2 Q96KS0 1/20 0.36
NSD2 O96028 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL4122380 0.91 ACHE (0.41) ACHEHTR2AHTR2CSLC6A4
SCHEMBL4121012 0.90 GPR119 (0.39) GPR119CSF1RKDRKDM4EPKM
SCHEMBL4121734 0.89 GPR119 (0.38) GPR119CSF1RKDRKDM4EPKM
Dimethylamine SCHEMBL4119922 0.88 ACHE (0.46) GPR119CSF1RKDRKDM4EPKM
Dimethylamine SCHEMBL4122314 0.88 GPR119 (0.43) GPR119CETPACHEEGLN2
Dimethylamine SCHEMBL4127824 0.86 CETP (0.38) GPR119CSF1RKDRKDM4EPKM
Dimethylamine SCHEMBL4129875 0.86 PDCD1 (0.42) GPR119CSF1RKDRCETPACHE
Dimethylamine SCHEMBL4120753 0.86 GPR119 (0.38) GPR119CSF1RKDRCETPTBK1
Dimethylamine SCHEMBL4126290 0.86 CSF1R (0.45) GPR119CSF1RKDRKDM4EPKM
Dimethylamine SCHEMBL4122129 0.86 GPR119 (0.41) GPR119CSF1RKDRKDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090318690-A1 Benzisoxazole Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-12-24 US disclosed
EP-2017275-A1 BENZISOXAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2009-01-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318690-A1 Benzisoxazole Compound NR1I2, NR1I3, NR0B1 GPR119 122/4885CSF1R 628/4885KDR 3127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.