Dimethylamine

Dimethylamine

SCHEMBL4129875

CNC.Cc1c(OCc2cccc(C#N)c2)ccc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc12

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 2/20 0.42
CD274 Q9NZQ7 2/20 0.42
ACHE P22303 3/20 0.42
CETP P11597 2/20 0.40
HTR6 P50406 2/20 0.40
YAP1 P46937 3/20 0.39
IRAK4 Q9NWZ3 1/20 0.38
NOTCH1 P46531 1/20 0.38
MGLL Q99685 1/20 0.38
CSF1R P07333 2/20 0.37
KDR P35968 1/20 0.37
BCHE P06276 1/20 0.37
GPR119 Q8TDV5 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL4122314 0.92 GPR119 (0.43) ACHECETPYAP1IRAK4GPR119
Dimethylamine SCHEMBL4126764 0.92 ACHE (0.46) PDCD1CD274ACHEHTR6MGLL
SCHEMBL4122438 0.90 ACHE (0.42) PDCD1CD274ACHECETPYAP1
Dimethylamine SCHEMBL4119922 0.89 ACHE (0.46) ACHEYAP1CSF1RKDRBCHE
SCHEMBL4129872 0.88 ACHE (0.41) PDCD1CD274ACHECETPYAP1
Dimethylamine SCHEMBL4120798 0.87 CETP (0.39) ACHECETPIRAK4GPR119
Dimethylamine SCHEMBL4121737 0.86 GPR119 (0.39) ACHECETPCSF1RKDRGPR119
Dimethylamine SCHEMBL4127824 0.86 CETP (0.38) ACHECETPCSF1RKDRGPR119
Dimethylamine SCHEMBL4136631 0.86 CETP (0.44) ACHECETPIRAK4NOTCH1CSF1R
Dimethylamine SCHEMBL4127332 0.86 EPHA2 (0.42) ACHEYAP1CSF1RKDRBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090318690-A1 Benzisoxazole Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-12-24 US disclosed
EP-2017275-A1 BENZISOXAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2009-01-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318690-A1 Benzisoxazole Compound NR1I2, NR1I3, NR0B1 PDCD1 4671/4885CD274 4381/4885ACHE 3716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.