SCHEMBL4124534

SCHEMBL4124534

Cn1cc(C(=O)Nc2ccccc2-c2cc(F)ccc2Cl)c(C(F)(F)F)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.54
POLB P06746 1/20 0.54
NTRK1 P04629 4/20 0.44
TRPV1 Q8NER1 1/20 0.43
STING1 Q86WV6 1/20 0.41
ATM Q13315 1/20 0.41
WDR5 P61964 2/20 0.41
JAK2 O60674 1/20 0.41
JAK1 P23458 1/20 0.41
TYK2 P29597 1/20 0.41
JAK3 P52333 1/20 0.41
LRRK2 Q5S007 1/20 0.41
NPSR1 Q6W5P4 2/20 0.40
PSEN1 P49768 1/20 0.40
PSEN2 P49810 1/20 0.40
APH1B Q8WW43 1/20 0.40
NCSTN Q92542 1/20 0.40
APH1A Q96BI3 1/20 0.40
PSENEN Q9NZ42 1/20 0.40
P2RX7 Q99572 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL302426 0.91 LMNA (0.64) LMNAPOLBNTRK1STING1ATM
SCHEMBL120547 0.90 LMNA (0.54) LMNAPOLBNTRK1STING1ATM
SCHEMBL29419095 0.90 LMNA (0.54) LMNAPOLBNTRK1STING1ATM
SCHEMBL302989 0.90 POLB (0.61) LMNAPOLBNTRK1STING1ATM
SCHEMBL675130 0.88 LMNA (0.51) LMNAPOLBNTRK1STING1ATM
SCHEMBL4445834 0.87 LMNA (0.50) LMNAPOLBNTRK1STING1ATM
SCHEMBL15063349 0.86 LMNA (0.51) LMNAPOLBNTRK1STING1WDR5
SCHEMBL303303 0.85 LMNA (0.53) LMNAPOLBNTRK1STING1WDR5
SCHEMBL29445385 0.85 LMNA (0.53) LMNAPOLBNTRK1STING1WDR5
SCHEMBL2351992 0.85 LMNA (0.55) LMNAPOLBNTRK1TRPV1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-09-24 US claimed
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides CBR3, CBR1, SNU13 LMNA 3235/4885POLB 3649/4885NTRK1 3674/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.