SCHEMBL4445834

SCHEMBL4445834

Cc1cc(F)ccc1-c1ccccc1NC(=O)c1cn(C)nc1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.50
POLB P06746 1/20 0.50
NTRK1 P04629 2/20 0.45
ATM Q13315 1/20 0.44
STING1 Q86WV6 1/20 0.42
WDR5 P61964 2/20 0.41
ALDH1A1 P00352 2/20 0.40
MAPK1 P28482 2/20 0.40
KDM4E B2RXH2 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
NTSR1 P30989 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SLC2A1 P11166 1/20 0.40
SLC2A3 P11169 1/20 0.40
SLC2A4 P14672 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL675130 0.91 LMNA (0.51) LMNAPOLBNTRK1ATMSTING1
SCHEMBL13955088 0.91 LMNA (0.51) LMNAPOLBNTRK1ATMSTING1
SCHEMBL13936356 0.89 LMNA (0.56) LMNAPOLBNTRK1ATMSTING1
SCHEMBL4455673 0.89 LMNA (0.60) LMNAPOLBNTRK1ATMSTING1
SCHEMBL120547 0.89 LMNA (0.54) LMNAPOLBNTRK1ATMSTING1
SCHEMBL29419095 0.89 LMNA (0.54) LMNAPOLBNTRK1ATMSTING1
SCHEMBL4446436 0.87 LMNA (0.47) LMNAPOLBNTRK1ALDH1A1KDM4E
SCHEMBL4124534 0.87 LMNA (0.54) LMNAPOLBNTRK1ATMSTING1
SCHEMBL13936348 0.85 NTRK1 (0.59) LMNAPOLBNTRK1ATMSTING1
SCHEMBL303186 0.85 LMNA (0.56) LMNAPOLBNTRK1ATMSTING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090042724-A1 Fungicidal mixtures based on 2,4-disubstituted n-biphenylpyrazolecarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US claimed
US-20090042724-A1 Fungicidal mixtures based on 2,4-disubstituted n-biphenylpyrazolecarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042724-A1 Fungicidal mixtures based on 2,4-disubstituted n-biphenylpyrazolecarboxamides CBR3, CBR1, SNU13 LMNA 3266/4885POLB 3502/4885NTRK1 3708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.