Dimethylamine

Dimethylamine

SCHEMBL4126427

CNC.Cc1c(OCc2ccccc2C#N)ccc2c(CCC3CCNCC3)noc12

nearest known ligand 0.39

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
MAOB P27338 1/20 0.38
ACHE P22303 4/20 0.37
GABRA1 P14867 2/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
GABRA5 P31644 2/20 0.36
GABRA3 P34903 2/20 0.36
GABRA2 P47869 2/20 0.36
KMT2A Q03164 1/20 0.35
BCHE P06276 1/20 0.34
SLC6A2 P23975 1/20 0.34
HTR6 P50406 1/20 0.34
SGMS2 Q8NHU3 1/20 0.34
ALDH1A1 P00352 2/20 0.33
IKBKE Q14164 1/20 0.33
TBK1 Q9UHD2 1/20 0.33
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL4112593 0.86 ACHE (0.39) MAOBACHEBCHEHTR6ALDH1A1
SCHEMBL4126422 0.86 SLC6A4 (0.36) SLC6A4HTR2AHTR2CMAOBACHE
Dimethylamine SCHEMBL4122380 0.86 ACHE (0.41) SLC6A4HTR2AHTR2CMAOBACHE
Dimethylamine SCHEMBL4120582 0.86 ACHE (0.56) ACHEBCHE
Dimethylamine SCHEMBL4121455 0.85 HTR6 (0.52) SLC6A4MAOBACHEHTR6SGMS2
Dimethylamine SCHEMBL4131906 0.85 ACHE (0.55) ACHEBCHE
Dimethylamine SCHEMBL4120903 0.84 ACHE (0.41) SLC6A4HTR2AHTR2CACHEGABRA1
Dimethylamine SCHEMBL4126478 0.84 ACHE (0.33) ACHEHTR6
Dimethylamine SCHEMBL4115122 0.83 CHEK1 (0.36) ACHEBCHEHTR6
Dimethylamine SCHEMBL4121737 0.83 GPR119 (0.39) SLC6A4HTR2AHTR2CACHETBK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090318690-A1 Benzisoxazole Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-12-24 US disclosed
EP-2017275-A1 BENZISOXAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2009-01-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318690-A1 Benzisoxazole Compound NR1I2, NR1I3, NR0B1 SLC6A4 1398/4885HTR2A 1251/4885HTR2C 529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.