Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CDC14B | O60729 | 1/20 | 0.47 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25056552 | 0.80 | CDC14B (0.47) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL6006641 | 0.80 | CDC14B (0.47) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL21858074 | 0.80 | CDC14B (0.44) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL19537979 | 0.80 | CA1 (0.44) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL30892322 | 0.80 | CA1 (0.44) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL19409989 | 0.76 | ALDH1A1 (0.44) | MAOAALDH1A1HPGDHSD17B10CYP3A4 | |
| SCHEMBL21624973 | 0.76 | CYP3A4 (0.46) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL29054008 | 0.74 | CDC14B (0.40) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL2195718 | 0.73 | MAOA (0.54) | MAOAALDH1A1KDM4EHPGDGLA | |
| SCHEMBL1635475 | 0.73 | MAOA (0.59) | MAOAALDH1A1KDM4EHPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2248424-A | — | — | None | — | — | JP | disclosed |
| US-9688612-B2 | Axially chiral N-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl] acetamide compound and chirality interconversion method of a-amino acid using the same | HAMARI CHEMICALS, LTD. (JP) | 2017-06-27 | — | — | US | disclosed |
| US-20150321994-A1 | AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL] ACETAMIDE COMPOUND AND CHIRALITY INTERCONVERSION METHOD OF ALPHA-AMINO ACID USING THE SAME | Hamari Chemicals, Ltd. 4-29 (JP) | 2015-11-12 | — | — | US | disclosed |
| US-20090035394-A1 | USE OF DNA-PK INHIBITION TO SENSITISE ATM DEFICIENT CANCERS TO DNA-DAMAGING CANCER THERAPIES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2009-02-05 | — | — | US | disclosed |
| EP-1895997-A2 | USE OF DNA-PK INHIBITION TO SENSITISE ATM DEFICIENT CANCERS TO DNA-DAMAGING CANCER THERAPIES | Kudos Pharmaceuticals Ltd (GB) | 2008-03-12 | — | — | EP | disclosed |
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |
| WO-2006126010-A2 | USE OF DNA-PK INHIBITION TO SENSITISE ATM DEFICIENT CANCERS TO DNA-DAMAGING CANCER THERAPIES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-11-30 | — | — | WO | disclosed |
| EP-1207161-B1 | NOVEL ISOINDOLE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2006-01-18 | — | — | EP | disclosed |
| EP-1123918-B1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6777410-B2 | SUCH AS 9-(2-METHOXYPHENYL)-3-(1-METHYLETHYL)-(1,3)OXAZOLO-(2,3)ISOINDOLE-2,5(3H,9H)-DIONE; DIABETES AND COMPLICATIONS; OBESITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-08-17 | — | — | US | disclosed |
| US-20040053923-A1 | Novel isoindole derivatives | BANYU PHARMACEUTICAL CO., LTD. | 2004-03-18 | — | — | US | disclosed |
| US-6608098-B1 | Diabetes or obesity, 2-(4-(3-isopropyl-2,5-dioxo-2,3-dihydro-1H-pyrrolo(2,1-a) isoindol-9(5H)-yl)phenoxy)-N-propylacetamide | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1207161-A1 | NOVEL ISOINDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | disclosed |
| EP-1123918-A1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |
| US-5965613-A | FUNGICIDES FOR USE IN AGRICULTURE AND HORTICULTURE; THE COMPOUNDS ALSO HAVE INSECTICIDAL AND ACARICIDAL ACTIVITY | NOVARTIS FINANCE CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| JP-H02248424-A | AROMATIC POLYMERS | IMPERIAL CHEM IND PLC <ICI> | 1990-10-04 | — | — | JP | disclosed |
| US-4764618-A | TRYPSIN INHIBITOR, PANCREATITIS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1988-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035394-A1 | USE OF DNA-PK INHIBITION TO SENSITISE ATM DEFICIENT CANCERS TO DNA-DAMAGING CANCER THERAPIES | ATM, CHEK2, DCK | MAOA 4741/4885ALDH1A1 3562/4885KDM4E 1271/4885 |
| US-20150321994-A1 | AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL] ACETAMIDE COMPOUND AND CHIRALITY INTERCONVERSION METHOD OF ALPHA-AMINO ACID USING THE SAME | ANPEP, NAAA, NAA15 | MAOA 1328/4885ALDH1A1 1672/4885KDM4E 695/4885 |
| US-20040053923-A1 | Novel isoindole derivatives | GPR119, SLC5A2, SLC5A1 | MAOA 558/4885ALDH1A1 228/4885KDM4E 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.