SCHEMBL4127259

SCHEMBL4127259

CCCCCC12CCC([C]=O)(CC1)CC2

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.34
HSD11B2 P80365 1/20 0.34
CCR2 P41597 1/20 0.33
DPP4 P27487 1/20 0.33
FAP Q12884 1/20 0.33
DPP7 Q9UHL4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10783825 0.82 TSHR (0.41) HSD11B1HSD11B2CCR2DPP4FAP
SCHEMBL10787187 0.79 TSHR (0.47) HSD11B1HSD11B2
SCHEMBL10782756 0.77 HSD11B1 (0.39) HSD11B1HSD11B2CCR2DPP4FAP
SCHEMBL12495350 0.75 HSD11B1 (0.32) HSD11B1HSD11B2CCR2DPP4FAP
SCHEMBL10783104 0.73 HSD11B1 (0.37) HSD11B1HSD11B2CCR2DPP4FAP
SCHEMBL10534982 0.71 TSHR (0.38) HSD11B1HSD11B2CCR2
SCHEMBL10536618 0.71 TSHR (0.38) HSD11B1HSD11B2CCR2
SCHEMBL10536837 0.71 TSHR (0.38) HSD11B1HSD11B2CCR2
SCHEMBL7024274 0.71 HSD11B1 (0.36) HSD11B1HSD11B2CCR2DPP4FAP
SCHEMBL10536845 0.71 TSHR (0.38) HSD11B1HSD11B2CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0948361-B1 MAGNETIC RESONANCE BLOOD POOL AGENTS MALLINCKRODT INC (US) 2005-01-26 EP claimed
US-20090247739-A1 CELLULOSIC SUBSTANCE COMPOSITION, CELLULOSIC SUBSTANCE FILM, OPTICALLY COMPENSATORY FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
US-20080241430-A1 CELLULOSE COMPOUND COMPOSITION, CELLULOSE COMPOUND FILM, OPTICALLY COMPENSATORY SHEET, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2008-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247739-A1 CELLULOSIC SUBSTANCE COMPOSITION, CELLULOSIC SUBSTANCE FILM, OPTICALLY COMPENSATORY FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE CUTA, FUCA1, GHDC HSD11B1 795/4885HSD11B2 577/4885CCR2 610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.