Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.59 |
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.59 |
| ▸ | MITF | O75030 | 3/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | XBP1 | P17861 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147199 | 0.81 | RAB9A (0.46) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8281626 | 0.77 | NPC1 (0.60) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8544400 | 0.77 | NPC1 (0.64) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4786381 | 0.77 | NPC1 (0.55) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9377180 | 0.74 | NPC1 (0.56) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4183392 | 0.72 | NPC1 (0.54) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2888709 | 0.70 | NPC1 (0.75) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4292263 | 0.70 | NPC1 (0.50) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9233774 | 0.69 | SMN1; SMN2 (0.50) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2893856 | 0.69 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032179-A1 | PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI | IDENIX PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | WO | disclosed |
| US-20090060867-A1 | PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI | IDENIX PHARMACEUTICALS, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090060867-A1 | PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI | IDENIX PHARMACEUTICALS, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090060867-A1 | PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI | IDENIX PHARMACEUTICALS, INC. (US) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090060867-A1 | PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI | POLR2E, POLR2H, POLI | NPC1 3467/4885RAB9A 3405/4885ALDH1A1 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.