Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.60 |
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.60 |
| ▸ | MITF | O75030 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8283496 | 0.78 | RAB9A (0.48) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4786381 | 0.77 | NPC1 (0.55) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4128504 | 0.77 | NPC1 (0.59) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8282666 | 0.73 | KMT2A (0.69) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4183392 | 0.73 | NPC1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9763242 | 0.70 | HTT (0.55) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4047300 | 0.70 | ALDH1A1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4292263 | 0.70 | NPC1 (0.50) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13620238 | 0.70 | RAB9A (0.55) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20985820 | 0.69 | KMT2A (0.49) | NPC1RAB9ASMN1; SMN2MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077915-A1 | PYRIDAZINONES AS ANTAGONISTS OF A4 INTEGRINS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-25 | — | — | WO | disclosed |