Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.50 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24445666 | 0.83 | ALDH1A1 (0.61) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| SCHEMBL20869201 | 0.80 | ALDH1A1 (0.66) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| SCHEMBL1414751 | 0.78 | ALDH1A1 (0.54) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| Isovanillin SCHEMBL1535672 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| Isovanillin SCHEMBL70256 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| Isovanillin SCHEMBL29396443 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| SCHEMBL27939271 | 0.77 | ALDH1A1 (0.41) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| SCHEMBL18196640 | 0.75 | ALDH1A1 (0.73) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| Isovanillin SCHEMBL28052909 | 0.75 | ALDH1A1 (0.93) | ALDH1A1AOX1TRIM24HPGDALDH5A1 | |
| Isovanillin SCHEMBL8703725 | 0.73 | ALDH1A1 (0.89) | ALDH1A1AOX1TRIM24HPGDALDH5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048247-A1 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE - IV | RANBAXY LABORATORIES LIMITED (IN) | 2009-02-19 | — | — | US | disclosed |
| EP-1869054-A2 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | Ranbaxy Laboratories Limited (IN) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006085212-A2 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | RANBAXY LABORATORIES LIMITED (IN) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048247-A1 | CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE - IV | PDE3B, PDE4A, PDE3A | ALDH1A1 894/4885AOX1 241/4885TRIM24 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.