Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10738814 | 0.90 | KDM4E (0.43) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2964830 | 0.87 | SMN1; SMN2 (0.43) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7527527 | 0.87 | CYP3A4 (0.46) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL13596070 | 0.87 | MEN1 (0.37) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL4121254 | 0.86 | GABRA1 (0.37) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL4121257 | 0.86 | GABRA1 (0.37) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL9303754 | 0.80 | ALDH1A1 (0.48) | GABRA1GABRB2ALDH1A1KDM4EMAPT | |
| SCHEMBL31657717 | 0.80 | ALDH1A1 (0.48) | GABRA1GABRB2ALDH1A1KDM4EMAPT | |
| SCHEMBL481043 | 0.79 | PPARG (0.45) | MAPTMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL8887655 | 0.77 | KDM4E (0.42) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| EP-2017275-A1 | BENZISOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
| EP-2017275-A1 | BENZISOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-7030245-B2 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenathrene | WYETH (US) | 2006-04-18 | — | — | US | disclosed |
| US-20050228010-A1 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-10-13 | — | — | US | disclosed |
| US-6930109-B2 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-08-16 | — | — | US | disclosed |
| US-6903110-B2 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040235851-A1 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH | 2004-11-25 | — | — | US | disclosed |
| US-20030078268-A1 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2003-04-24 | — | — | US | disclosed |
| WO-2003010169-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 7, 8-DIHYDRO-6H-5-OXA-1-AZA-PHENANTHRENE | WYETH (US) | 2003-02-06 | — | — | WO | disclosed |
| US-4474787-A | 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof | FISONS LIMITED (GB) | 1984-10-02 | — | — | US | disclosed |
| US-4419352-A | ANTIALLERGENS; ANTI SECRETORY AGENTS; MUCUS | FISONS LIMITED (GB) | 1983-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078268-A1 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | TPH1, CYP19A1, HSD3B1 | GABRA1 1324/4885GABRA5 855/4885GABRA3 1405/4885 |
| US-20040235851-A1 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | TPH1, CYP19A1, HSD3B1 | GABRA1 1229/4885GABRA5 823/4885GABRA3 1338/4885 |
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | GABRA1 7/4885GABRA5 14/4885GABRA3 17/4885 |
| US-20050228010-A1 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | HTR5A, TPH1, CYP19A1 | GABRA1 1566/4885GABRA5 773/4885GABRA3 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.