Grinimibine

Grinimibine

SCHEMBL4132680

Cc1cc2c([nH]c3ccccc32)c2c1OC(C)(C)C=C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 1.00
▸ POLB P06746 2/20 1.00
▸ XBP1 P17861 2/20 1.00
▸ NPC1 O15118 1/20 1.00
▸ RAB9A P51151 1/20 1.00
▸ KMT2A Q03164 6/20 0.63
▸ MEN1 O00255 5/20 0.63
▸ PNLIP P16233 1/20 0.63
▸ HSD17B10 Q99714 4/20 0.56
▸ NPSR1 Q6W5P4 3/20 0.47
▸ GAA P10253 2/20 0.47
▸ IDE P14735 1/20 0.47
▸ KIF11 P52732 2/20 0.42
▸ KDM4E B2RXH2 3/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ HPGD P15428 3/20 0.42
▸ TSHR P16473 2/20 0.42
▸ CYP2C19 P33261 2/20 0.42
▸ LMNA P02545 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29502491 0.84 MAPT (0.72) MAPTPOLBXBP1NPC1RAB9A
Koenimbine SCHEMBL29581663 0.82 MAPT (0.69) MAPTPOLBXBP1NPC1RAB9A
SCHEMBL30929792 0.82 MAPT (0.69) MAPTPOLBXBP1NPC1RAB9A
SCHEMBL3310991 0.81 MAPT (0.66) MAPTPOLBXBP1NPC1RAB9A
SCHEMBL30929796 0.79 MAPT (0.65) MAPTPOLBXBP1NPC1RAB9A
Mahanimbine SCHEMBL2991765 0.78 MAPT (1.00) MAPTPOLBXBP1NPC1RAB9A
Mahanimbine SCHEMBL18488203 0.78 MAPT (1.00) MAPTPOLBXBP1NPC1RAB9A
Mahanimbine SCHEMBL18488200 0.78 MAPT (1.00) MAPTPOLBXBP1NPC1RAB9A
SCHEMBL29814874 0.77 MAPT (0.62) MAPTPOLBXBP1NPC1RAB9A
SCHEMBL31324179 0.75 MAPT (0.60) MAPTPOLBXBP1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114272323-A Traditional Chinese medicine formula for regulating and controlling intestinal function of lactating women 华子昂 2022-04-05 — — CN claimed
US-20250281559-A1 DRUG FOR TREATMENT OF BREAST CANCER WITH ANTLER AND GINSENG AS SOVEREIGN DRUG AND PREPARATION METHOD AND APPLICATION THEREOF JILIN UNIVERSITY (CN) 2025-09-11 — — US disclosed
EP-4099976-B1 MURRAYA KOENIGII EXTRACT AND USE THEREOF IN COSMETICS GATTEFOSSE SAS (FR) 2024-12-04 — — EP disclosed
US-20240390446-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES AND THYROID DISEASES ALKALAY RACHEL (IL) 2024-11-28 — — US disclosed
EP-4404923-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES AND THYROID DISEASES Alkalay, Rachel (IL) 2024-07-31 — — EP disclosed
US-20240226218-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING A CORONAVIRUS INFECTION Novel Concepts Medical Ltd (IL) 2024-07-11 — — US disclosed
CN-118141926-A Application of plant carbazole alkaloid in preparation of iron death inhibitor 北京大学 2024-06-07 — — CN disclosed
CN-117059172-A Method for analyzing action mechanism of ginseng for improving erection dysfunction 广州康兮乐健康科技有限公司 2023-11-14 — — CN disclosed
US-20230346866-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NON-MALIGNANT RESPIRATORY DISEASE Novel Concepts Medical Ltd (IL) 2023-11-02 — — US disclosed
US-20230181665-A1 TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES MELLITUS 10 TYPE I AND TYPE II AND THYROID DISEASES Novel Concepts Medical Ltd (IL) 2023-06-15 — — US disclosed
US-20180052161-A1 BIOMARKERS FOR MALARIA DIAGNOSIS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2018-02-22 — — US disclosed
WO-2016149386-A1 BIOMARKERS FOR MALARIA DIAGNOSIS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2016-09-22 — — WO disclosed
US-20090104297-A1 HERBAL COMPOSITION FOR TREATMENT OF INFECTIONS CAUSED BY DERMATOPHYTES PIRAMAL LIFE SCIENCES LIMITED (IN) 2009-04-23 — — US disclosed
CN-100478022-C Synergistic composition for treating hyperlipidemia COUNCIL SCIENT IND RES (IN) 2009-04-15 — — CN disclosed
EP-1998727-A2 HERBAL COMPOSITION FOR TREATMENT OF INFECTIONS CAUSED BY DERMATOPHYTES Piramal Life Sciences Limited (IN) 2008-12-10 — — EP disclosed
WO-2007110837-A2 HERBAL COMPOSITION FOR TREATMENT OF INFECTIONS CAUSED BY DERMATOPHYTES PIRAMAL LIFE SCIENCES LIMITED (IN) 2007-10-04 — — WO disclosed
CN-1893965-A Synergistic composition for treating hyperlipemia COUNCIL SCIENT IND RES (IN) 2007-01-10 — — CN disclosed
US-6989165-B2 Synergistic composition for treating hyperilipdemia COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2006-01-24 — — US disclosed
WO-2005070442-A1 A SYNERGISTIC COMPOSITION FOR TREATING HYPERLIPIDEMIA COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2005-08-04 — — WO disclosed
US-20050136138-A1 Synergistic composition for treating hyperilipdemia COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2005-06-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240390446-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES AND THYROID DISEASES TPO, TNF, ADAMTS13 MAPT 2143/4885POLB 4693/4885XBP1 655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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