Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.44 |
| ▸ | TUBB | P07437 | 8/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123012 | 1.00 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL4121479 | 0.97 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6113045 | 0.89 | KDM4E (0.64) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6113256 | 0.85 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL7172176 | 0.83 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6113089 | 0.83 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6112770 | 0.79 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL11708730 | 0.79 | BRD4 (0.46) | KDM4EALDH1A1HPGDMAPTBRD4 | |
| SCHEMBL1274675 | 0.79 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL6112675 | 0.79 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896391-B1 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | UNIV BAYLOR (US) | 2015-08-12 | — | — | EP | disclosed |
| US-20140291660-A1 | Organic Electroluminescent Element, Material for Organic Electroluminescent Element and Light Emitting Device, Display Device, and Illumination Device, Each Employing Organic Electroluminescent Element | UDC IRELAND LIMITED (IE) | 2014-10-02 | — | — | US | disclosed |
| US-8394859-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2013-03-12 | — | — | US | disclosed |
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |
| US-20120130129-A1 | Efficient Method for Preparing Functionalized Benzosuberenes | BAYLOR UNIVERSITY (US) | 2012-05-24 | — | — | US | disclosed |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | BAYLOR UNIVERSITY | 2009-03-19 | — | — | US | disclosed |
| US-7429681-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2008-09-30 | — | — | US | disclosed |
| EP-1896391-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | Baylor University (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| WO-2006138427-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | BAYLOR UNIVERSITY (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130129-A1 | Efficient Method for Preparing Functionalized Benzosuberenes | CYP2B6, CYP2A6, GABRA6 | KDM4E 232/4885ALDH1A1 1302/4885HPGD 599/4885 |
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | TUBB, TUBB3, TUBB1 | KDM4E 4221/4885ALDH1A1 4033/4885HPGD 3200/4885 |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | TUBB, TUBB3, TUBB1 | KDM4E 4221/4885ALDH1A1 4033/4885HPGD 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.