Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.66 |
| ▸ | USP2 | O75604 | 7/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.66 |
| ▸ | PGR | P06401 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.66 |
| ▸ | CNR1 | P21554 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amcinonide SCHEMBL8420886 | 0.91 | CYP3A4 (0.80) | USP2NR3C1CYP3A4PGRLMNA | |
| Betamethasone Dipropionate SCHEMBL7120868 | 0.82 | NR3C1 (0.68) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL1649481 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL4720 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL21051752 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL13026154 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL5488922 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Amcinonide SCHEMBL12396698 | 0.81 | HIF1A (1.00) | USP2NR3C1CYP3A4PGRLMNA | |
| Betamethasone Dipropionate SCHEMBL3048282 | 0.81 | NR3C1 (0.79) | USP2NR3C1CYP3A4PGRLMNA | |
| SCHEMBL25370010 | 0.80 | NR3C1 (0.91) | USP2NR3C1CYP3A4PGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106278999-B | S1P regulator | 比奥根MA公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-106278999-A | S1p regulator | 比奥根MA公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-103533835-B | S1P modulators | 比奥根MA公司 | 2016-08-24 | — | — | CN | disclosed |
| US-20090075958-A1 | CLOBETASOL PROPIONATE SHAMPOOS FOR THE TREATMENT OF SEBORRHEIC DERMATITIS OF THE SCALP | BISTUER FLORENCE | 2009-03-19 | — | — | US | disclosed |
| US-20080275014-A1 | Clobetasol Propionate Shampoos for the Treatment of Seborrheic Dermatitis of the Scalp | GALDERMA S.A. (CH) | 2008-11-06 | — | — | US | disclosed |
| EP-1824448-A1 | CLOBETASOL PROPIONATE SHAMPOOS FOR THE TREATMENT OF SEBORRHEIC DERMATITIS OF THE SCALP | Galderma S.A. (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-20060134055-A1 | Clobetasol propionate shampoos for the treatment of seborrheic dermatitis of the scalp | GALDERMA S.A. (CH) | 2006-06-22 | — | — | US | disclosed |
| WO-2006061260-A1 | CLOBETASOL PROPIONATE SHAMPOOS FOR THE TREATMENT OF SEBORRHEIC DERMATITIS OF THE SCALP | GALDERMA S.A. (CH) | 2006-06-15 | — | — | WO | disclosed |