Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.68 |
| ▸ | PGR | P06401 | 7/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone Dipropionate SCHEMBL3048282 | 0.93 | NR3C1 (0.79) | NR3C1PGRNR1I2MAPTADORA3 | |
| Beclomethasone Dipropionate SCHEMBL9954979 | 0.89 | CYP3A4 (0.72) | NR3C1PGRNR1I2MAPTADORA3 | |
| Betamethasone Valerate SCHEMBL8449742 | 0.87 | NR3C1 (0.64) | NR3C1PGRNR1I2MAPTCYP3A4 | |
| Desonide SCHEMBL11778722 | 0.86 | CYP3A4 (0.73) | NR3C1PGRNR1I2MAPTCYP3A4 | |
| Amcinonide SCHEMBL1832816 | 0.84 | LMNA (0.77) | NR3C1PGRNR1I2MAPTCYP3A4 | |
| Desonide SCHEMBL2115498 | 0.84 | CYP3A4 (0.75) | NR3C1PGRNR1I2MAPTCYP3A4 | |
| Beclomethasone Dipropionate SCHEMBL266055 | 0.83 | NR3C1 (0.65) | NR3C1PGRNR1I2MAPTADORA3 | |
| Clobetasol Propionate SCHEMBL1561443 | 0.83 | CYP3A4 (0.72) | NR3C1PGRNR1I2MAPTADORA3 | |
| Triamcinolone Acetonide SCHEMBL9987506 | 0.83 | CYP3A4 (0.75) | NR3C1PGRNR1I2CYP3A4LMNA | |
| Amcinonide SCHEMBL8420886 | 0.83 | CYP3A4 (0.80) | NR3C1PGRNR1I2MAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6517847-B2 | For skin disorders, comprising a drug and a lightly crosslinked polyacrylic acid, a base to adjust the pH, water, and optionally: water miscible solvent, preservative, surfactant, oil phase; acne, rosacea | DOW PHARMACEUTICAL SCIENCES | 2003-02-11 | — | — | US | claimed |