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Amcinonide

Amcinonide

SCHEMBL8420886

CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Amcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.80
▸ CYP3A4 P08684 8/20 0.80
▸ PGR P06401 6/20 0.80
▸ USP2 O75604 6/20 0.80
▸ LMNA P02545 6/20 0.80
▸ HIF1A Q16665 5/20 0.80
▸ MAPT P10636 3/20 0.80
▸ CNR1 P21554 3/20 0.80
▸ NPSR1 Q6W5P4 2/20 0.80
▸ KCNH2 Q12809 1/20 0.80
▸ NR1I2 O75469 3/20 0.75
▸ ADORA3 P0DMS8 2/20 0.75
▸ DRD2 P14416 1/20 0.75
▸ OPRD1 P41143 1/20 0.75
▸ SMN1; SMN2 Q16637 2/20 0.64
▸ CYP2C9 P11712 2/20 0.64
▸ MLNR O43193 1/20 0.64
▸ ABCB11 O95342 1/20 0.64
▸ CYP3A5 P20815 1/20 0.64
▸ PPARG P37231 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amcinonide SCHEMBL4134632 0.91 USP2 (0.66) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL13026154 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL21051752 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL4720 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL5488922 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL12396698 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Amcinonide SCHEMBL1649481 0.89 HIF1A (1.00) CYP3A4NR3C1PGRUSP2LMNA
Betamethasone Dipropionate SCHEMBL3048282 0.89 NR3C1 (0.79) CYP3A4NR3C1PGRUSP2LMNA
SCHEMBL25370010 0.88 NR3C1 (0.91) CYP3A4NR3C1PGRUSP2LMNA
SCHEMBL8077638 0.88 NR3C1 (0.91) CYP3A4NR3C1PGRUSP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946146-A2 NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS Boehringer Ingelheim Pharma KG (DE) 1999-10-06 — — EP disclosed
WO-1998027959-A2 NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS BOEHRINGER INGELHEIM PHARMA KG (DE) 1998-07-02 — — WO disclosed
EP-0835098-A1 NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS BOEHRINGER INGELHEIM KG (DE) 1998-04-15 — — EP disclosed
WO-1997001329-A1 NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS BOEHRINGER INGELHEIM KG (DE) 1997-01-16 — — WO disclosed
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