Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131343 | 0.89 | ASIC3 (0.37) | ASIC3MCHR1HRH3KCNH2HTR2C | |
| SCHEMBL4135842 | 0.88 | CNR2 (0.43) | ASIC3MCHR1HRH3KCNH2FABP4 | |
| SCHEMBL4128118 | 0.87 | PDK1 (0.42) | ASIC3MCHR1HRH3KCNH2HTR2C | |
| SCHEMBL4141821 | 0.86 | ALDH1A1 (0.39) | ASIC3MCHR1HRH3KCNH2CYP3A4 | |
| SCHEMBL4133152 | 0.86 | ASIC3 (0.40) | ASIC3MCHR1HRH3KCNH2CYP3A4 | |
| SCHEMBL4142298 | 0.84 | HRH3 (0.39) | ASIC3MCHR1HRH3KCNH2HTR2C | |
| SCHEMBL4132423 | 0.84 | SIGMAR1 (0.38) | ASIC3HRH3HTR2CHTR2BHTR2A | |
| SCHEMBL4129121 | 0.83 | HRH3 (0.39) | ASIC3HRH3KCNH2CYP3A4 | |
| SCHEMBL4142343 | 0.83 | HRH3 (0.40) | ASIC3HRH3KCNH2CYP3A4 | |
| SCHEMBL4141241 | 0.83 | PGR (0.39) | MCHR1HRH3KCNH2GRM2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | ASIC3 388/4885MCHR1 287/4885HRH3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.