Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | LSS | P48449 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743819 | 0.83 | CHRNB2 (0.56) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20653365 | 0.83 | CHRNB2 (0.56) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL23252299 | 0.82 | CYP2D6 (1.00) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL23405947 | 0.81 | CHRNB2 (0.54) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL29743809 | 0.81 | CHRNB2 (0.54) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL29743873 | 0.81 | ACVR1B (0.58) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20641478 | 0.81 | ACVR1B (0.58) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20641506 | 0.80 | ACVR1B (0.46) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL22831331 | 0.80 | LSS (0.83) | CYP2D6CYP1A2LTA4HLSSACHE | |
| SCHEMBL410420 | 0.79 | TGFBR1 (0.67) | CYP2D6CYP1A2CYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | BETSCHART CLAUDIA | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | CTSK, CTSS, CTSZ | CYP2D6 2419/4885CYP1A2 3724/4885CYP19A1 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.