Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20951584 | 0.85 | EED (0.43) | SMN1; SMN2GAAALOX15MAPK1PSMB5 | |
| SCHEMBL20951586 | 0.85 | EED (0.43) | SMN1; SMN2GAAALOX15MAPK1PSMB5 | |
| SCHEMBL9832137 | 0.85 | ALDH1A1 (0.56) | TSHRSMN1; SMN2GAAALOX15MAPK1 | |
| SCHEMBL7897832 | 0.85 | ALDH1A1 (0.56) | TSHRSMN1; SMN2GAAALOX15MAPK1 | |
| SCHEMBL20951418 | 0.84 | CTSB (0.47) | CTSSCTSK | |
| SCHEMBL20951417 | 0.84 | CTSB (0.47) | CTSSCTSK | |
| SCHEMBL6562939 | 0.83 | ALDH1A1 (0.54) | TSHRSMN1; SMN2GAAALOX15MAPK1 | |
| SCHEMBL8581694 | 0.83 | ALDH1A1 (0.54) | TSHRSMN1; SMN2GAAALOX15MAPK1 | |
| SCHEMBL7896986 | 0.83 | ALDH1A1 (0.54) | TSHRSMN1; SMN2GAAALOX15MAPK1 | |
| SCHEMBL9829273 | 0.83 | ALDH1A1 (0.54) | TSHRSMN1; SMN2GAAALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | TSHR 2168/4885SMN1; SMN2 2937/4885GAA 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.